Engineering 3D Printed Gummies Loaded with Metformin for Paediatric Use

Area of Science:

• Pharmaceutical Technology
• Materials Science
• Paediatric Medicine

Background:

• Developing appealing and effective drug delivery systems is crucial for paediatric therapeutic adherence.
• 3D printing offers a novel approach for creating customizable and patient-friendly dosage forms.

Purpose of the Study:

• To produce 250 mg metformin paediatric gummies using semi-solid extrusion (SSE) 3D printing.
• To compare 3D printing and casting methodologies using a quality by design approach.
• To evaluate the physical properties and drug release profile of the 3D-printed gummies.

Main Methods:

• Formulation of a pharmaceutical ink with metformin for room-temperature SSE 3D printing.
• Utilizing a quality by design approach to optimize the manufacturing process.
• Comparison of 3D printing and traditional casting methods for gummy production.

Main Results:

• Successful formulation of a metformin-containing pharmaceutical ink with optimal flow properties.
• 3D-printed gummies demonstrated superior firmness and sustained drug release compared to casting.
• The 3D-printed gummies possessed desirable texture and physical appearance, mimicking commercial products.

Conclusions:

• Semi-solid extrusion 3D printing enables the successful manufacture of sugar-free metformin gummies for paediatric diabetes treatment.
• This 3D printing approach is a readily translatable method for clinical practice.
• The developed gummies enhance palatability and ensure effective drug delivery for paediatric patients.