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Related Concept Videos

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Repaglinide (Prandin) and Nateglinide (Starlix), known as glinides, are oral insulin secretagogues that stimulate insulin release from pancreatic β cells by closing the ATP-sensitive potassium channels (KATP channel). Repaglinide controls insulin release from pancreatic β cells by managing potassium efflux. It shares two binding sites with sulfonylureas and also has a unique site, indicating overlapping mechanisms of action. With a rapid onset and a 4-7 hour duration, it effectively...
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Biguanides, particularly metformin (Glucophage), are insulin sensitizers that enhance glucose uptake, thereby reducing insulin resistance. Unlike sulfonylureas, metformin doesn't prompt insulin secretion, which helps to curb hypoglycemia risk. Metformin is beneficial in treating conditions like polycystic ovary syndrome due to its insulin-resistance reduction capability. The drug's primary action involves curtailing hepatic gluconeogenesis, a significant contributor to high blood...
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Engineering 3D Printed Gummies Loaded with Metformin for Paediatric Use.

Karla J Santamaría1,2, Brayan J Anaya1, Aikaterini Lalatsa3,4

  • 1Pharmaceutics and Food Technology Department, Faculty of Pharmacy, Complutense University of Madrid, 28040 Madrid, Spain.

Gels (Basel, Switzerland)
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Summary

3D printing created appealing metformin gummies for children, improving adherence. This semi-solid extrusion technique offers a promising, customizable approach for paediatric drug delivery.

Keywords:
3D printed gummies3D printingmetforminpaediatricssemi-solid extrusion (SSE)

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Area of Science:

  • Pharmaceutical Technology
  • Materials Science
  • Paediatric Medicine

Background:

  • Developing appealing and effective drug delivery systems is crucial for paediatric therapeutic adherence.
  • 3D printing offers a novel approach for creating customizable and patient-friendly dosage forms.

Purpose of the Study:

  • To produce 250 mg metformin paediatric gummies using semi-solid extrusion (SSE) 3D printing.
  • To compare 3D printing and casting methodologies using a quality by design approach.
  • To evaluate the physical properties and drug release profile of the 3D-printed gummies.

Main Methods:

  • Formulation of a pharmaceutical ink with metformin for room-temperature SSE 3D printing.
  • Utilizing a quality by design approach to optimize the manufacturing process.
  • Comparison of 3D printing and traditional casting methods for gummy production.

Main Results:

  • Successful formulation of a metformin-containing pharmaceutical ink with optimal flow properties.
  • 3D-printed gummies demonstrated superior firmness and sustained drug release compared to casting.
  • The 3D-printed gummies possessed desirable texture and physical appearance, mimicking commercial products.

Conclusions:

  • Semi-solid extrusion 3D printing enables the successful manufacture of sugar-free metformin gummies for paediatric diabetes treatment.
  • This 3D printing approach is a readily translatable method for clinical practice.
  • The developed gummies enhance palatability and ensure effective drug delivery for paediatric patients.