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Biomedical Application of Enzymatically Crosslinked Injectable Hydrogels.

Minho Nam1, Jong Won Lee1, Gi Doo Cha1

  • 1Department of Systems Biotechnology, Chung-Ang University, Anseong 17546, Republic of Korea.

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|October 25, 2024
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Summary
This summary is machine-generated.

Injectable hydrogels offer minimally invasive delivery for biomedical applications. This review explores enzymatic crosslinking mechanisms, properties, and applications like wound healing and hemostasis for advanced biomaterials.

Keywords:
biomedical applicationenzymatic crosslinkinginjectable hydrogel

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Biomedical Engineering

Background:

  • Hydrogels possess tissue-like properties and can integrate fillers, making them valuable in biomedicine.
  • Injectable hydrogels are particularly advantageous for minimally invasive implantation.
  • Enzymatically crosslinked injectable hydrogels offer excellent biocompatibility and tunable mechanical properties.

Purpose of the Study:

  • To review the crosslinking mechanisms of enzymatically crosslinked injectable hydrogels.
  • To investigate the relationship between hydrogel parameters and intrinsic properties.
  • To present biomedical applications and analyze composite hydrogels with therapeutic fillers.

Main Methods:

  • Focus on enzymatic crosslinking mechanisms: horseradish peroxidase (HRP), transglutaminase (TG), and tyrosinase.
  • Analysis of parameters influencing hydrogel properties.
  • Review of applications and composite hydrogel formulations.

Main Results:

  • Enzymatic crosslinking provides control over hydrogel properties for specific uses.
  • Applications demonstrated in wound healing, preventing post-operative adhesion (POA), and hemostasis.
  • Hydrogel composites incorporating cells, proteins, and drugs show promise.

Conclusions:

  • Enzymatically crosslinked injectable hydrogels are versatile biomaterials.
  • Future development requires focus on material selection, property optimization, and filler integration.
  • Continued research will advance their use in regenerative medicine and drug delivery.