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Updated: Jun 9, 2025

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro

Published on: May 10, 2021

Computational Model for Early-Stage Aortic Valve Calcification Shows Hemodynamic Biomarkers.

Asad Mirza¹, Chia-Pei Denise Hsu¹, Andres Rodriguez¹

¹Department of Biomedical Engineering, Florida International University, Miami, FL 33174, USA.

Bioengineering (Basel, Switzerland)

|October 25, 2024

Summary

This summary is machine-generated.

Tracking hemodynamics may offer a new way to monitor early-stage heart valve calcification. This study found increased wall shear stress in calcified bioscaffold valves, suggesting a potential biomarker for calcific aortic valve disease (CAVD).

Keywords:

CAVD PSIS aortic valve bioscaffold fluid–structure interaction hemodynamics hydrodynamics nanoindentation tissue engineering

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Isolation and Characterization of Primary Rat Valve Interstitial Cells: A New Model to Study Aortic Valve Calcification

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Isolation and Characterization of Primary Rat Valve Interstitial Cells: A New Model to Study Aortic Valve Calcification

Isolation and Characterization of Primary Rat Valve Interstitial Cells: A New Model to Study Aortic Valve Calcification

Published on: November 20, 2017

Area of Science:

Biomaterials Science
Cardiovascular Research
Medical Engineering

Background:

Heart disease remains a leading cause of mortality globally.
Calcific aortic valve disease (CAVD) is the most common form, necessitating early detection for effective patient management.
Predictive markers for early CAVD are crucial for timely intervention before aortic valve replacement surgery.

Purpose of the Study:

To investigate hydrodynamic, mechanical, and hemodynamic differences between healthy and early-stage calcified porcine small intestinal submucosa (PSIS) bioscaffold valves.
To identify potential parameters for tracking CAVD progression.
To assess the suitability of PSIS bioscaffolds for modeling early CAVD.

Main Methods:

Three groups of PSIS valves were tested: raw (control), calcified (seeded with VICs/VECs) in static conditions, and calcified (seeded with VICs/VECs) in bioreactor oscillatory flow.
Hydrodynamic assessments and mechanical testing (Young's modulus) were performed.
Fluid-structure interaction (FSI) simulations were conducted to analyze hemodynamic parameters like time-averaged wall shear stress (TAWSS).

Main Results:

Hydrodynamic metrics in calcified valves were below thresholds for mild calcification.
A significant increase in Young's modulus was observed in calcified valves compared to raw PSIS, indicating altered tissue structure.
FSI simulations showed a significant increase in TAWSS in calcified valve groups compared to the raw control group.

Conclusions:

While hydrodynamic metrics were not indicative of early calcification, increased mechanical stiffness (Young's modulus) suggests structural changes.
Fluid-structure interaction simulations revealed a significant increase in time-averaged wall shear stress (TAWSS) in calcified valves.
Hemodynamic monitoring, specifically TAWSS, may serve as a viable biomarker for early-stage calcific aortic valve disease (CAVD) tracking.