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Related Experiment Videos

Glucagon and ureteric calculi.

D R Webb, I N Nunn, D McOmish

    The Medical Journal of Australia
    |February 3, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Glucagon was investigated for treating ureteric colic, but this study found it ineffective. The drug did not aid stone passage or reduce pain, with most patients still needing significant pain relief.

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    Area of Science:

    • Urology
    • Pharmacology

    Background:

    • Glucagon is a smooth muscle relaxant.
    • Its potential use for ureteric calculi and colic has been proposed.
    • Clinical application could reduce hospital admissions for colic.

    Purpose of the Study:

    • To evaluate glucagon's efficacy in managing acute ureteric colic.
    • To determine if glucagon aids stone passage or alleviates colic symptoms.

    Main Methods:

    • Ten patients with acute ureteric colic received 1mg glucagon intravenously.
    • Two liters of intravenous fluid and analgesia were administered over three hours.
    • Clinical and radiological monitoring tracked stone progression and passage.

    Main Results:

    Related Experiment Videos

  • No patients experienced significant stone progression or passage.
  • Seven out of ten patients required parenteral analgesia for pain.
  • Glucagon did not demonstrate effectiveness in managing ureteric colic.

    • Conclusions:

    • Glucagon is not effective for the symptomatic management of ureteric colic.
    • Its proposed role in facilitating ureteric stone passage is not supported by this study.
    • Current casualty department protocols for ureteric colic should not include glucagon.