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Antimicrobial Characterization of Advanced Materials for Bioengineering Applications
Published on: August 4, 2018
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Development of Novel Biocomposites with Antimicrobial-Activity-Based Magnesium-Doped Hydroxyapatite with Amoxicillin
Carmen Cimpeanu1, Daniela Predoi2, Carmen Steluta Ciobanu2
1Faculty of Land Reclamation and Environmental Engineering, University of Agronomic Sciences and Veterinary Medicine of Bucharest, 59 Marasti Blvd., 011464 Bucharest, Romania.
Antibiotics (Basel, Switzerland)
|October 25, 2024
Summary
A novel magnesium-doped hydroxyapatite and amoxicillin biocomposite (MgHApOx) was synthesized. This biocompatible material demonstrates significant antimicrobial activity, showing promise for new biomedical applications.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Materials Chemistry
Background:
- Hydroxyapatite (HAp) is a key biomaterial, but its applications can be enhanced with doping and functionalization.
- Developing novel biocomposites with combined biocompatibility and antimicrobial properties is crucial for advanced biomedical applications.
Purpose of the Study:
- To synthesize and characterize a novel magnesium-doped hydroxyapatite enriched with amoxicillin (MgHApOx) biocomposite.
- To evaluate the biocompatibility and antimicrobial efficacy of the synthesized MgHApOx for potential biomedical use.
Main Methods:
- Coprecipitation method for MgHApOx synthesis.
- Characterization using X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy, X-ray photoelectron spectroscopy (XPS), and scanning electron microscopy (SEM).
- In vitro assessment of biocompatibility using human fetal osteoblastic cells (hFOB 1.19) and antimicrobial activity against *Staphylococcus aureus*, *Escherichia coli*, and *Candida albicans*.
Main Results:
- XRD and XPS confirmed the successful synthesis of MgHApOx, retaining HAp characteristics with Mg2+ substitution and amoxicillin incorporation.
- SEM revealed crystalline nanoparticles with acicular flakes morphology and an average crystallite size of 17.79 nm.
- In vitro assays demonstrated good biocompatibility and significant antimicrobial activity of MgHApOx against tested microbial strains, influenced by antibiotic presence and incubation time.
Conclusions:
- MgHApOx biocomposite exhibits promising biocompatible and antimicrobial properties.
- The synthesized material is a potential candidate for developing new antimicrobial agents for biomedical applications.
