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The MESH-RTL Project for prevention of abdominal wound dehiscence (AWD) in high-risk patients: noninferiority,
Edgard Efrén Lozada Hernández1, Eduardo Flores González2, Jose Luis Chavarría Chavira2
1General Surgery, Department of Diseases of the Digestive Tract, Servicios de salud del Instituto Mexicano del Seguro Social Para El Bienestar (IMSS-BIENESTAR) Hospital Regional de Alta Especialidad del Bajío, Colonia Quinta los Naranjos, Circuito Quinta los Naranjos # 145 B, León, Guanajuato, México. edgardlozada2@gmail.com.
Purpose:
To compare reinforced tension line (RTL) and mesh techniques in the onlay position for preventing abdominal wound dehiscence (AWD) in a noninferiority clinical trial.
Methods:
Patients > 18 years old who underwent midline laparotomy and who were considered at high risk on the modified Rotterdam risk scale were included. The outcomes analyzed were the incidence of AWD and surgical site occurrence (SSO).
Results:
239 patients were included: 121 mesh group and 118 RTL group. Five (4.1%) of the 121 patients in the mesh group and 7 (5.9%) of the 118 patients in the RTL group presented with AWD (p = 0.56, RR = 0.69, 95% CI = 0.22-2.13) in the per-protocol analysis. The median time of presentation was 6 days. The 95% CI (-0.0567, 0.0231) for the difference in incidence between the two groups was entirely within the predefined noninferiority margin of 5%. The incidence of complications did not significantly differ between the two groups: the mesh group (27, 22.3%) and the RTL group (16, 12.8%) (p = 0.09, RR (95% CI) = 1.64 (0.93-2.89)).
Conclusion:
The use of the RTL technique for preventing AWD was not inferior to the use of mesh in the onlay position, nor did it increase the risk of complications. This study was registered on clinicaltrials.gov: Mesh-RTL Project (NCT04134455).
