Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Excess Pressure Inside a Drop and a Bubble01:13

Excess Pressure Inside a Drop and a Bubble

1.6K
The shape of a small drop of liquid can be considered spherical, neglecting the effect of gravity. This drop can further be considered as two equal hemispherical drops put together due to surface tension. The forces acting on the spherical drop are due to the pressure of the liquid inside the drop, the pressure due to air outside the drop, and the force due to the surface tension acting on the two hemispherical drops.
1.6K
Surface Tension of Fluid01:22

Surface Tension of Fluid

243
Surface tension is a fundamental property of fluids, occurring at the boundary between a liquid and a gas or between two immiscible liquids. This phenomenon arises from the cohesive forces between molecules at the fluid's surface, creating an effect similar to a stretched elastic membrane. Inside each fluid, molecules are equally attracted in all directions by neighboring molecules, but surface molecules experience a net inward force, resulting in surface tension.
Surface tension varies...
243
Surface Tension, Capillary Action, and Viscosity02:57

Surface Tension, Capillary Action, and Viscosity

27.5K
Surface Tension
The various IMFs between identical molecules of a substance are examples of cohesive forces. The molecules within a liquid are surrounded by other molecules and are attracted equally in all directions by the cohesive forces within the liquid. However, the molecules on the surface of a liquid are attracted only by about one-half as many molecules. Because of the unbalanced molecular attractions on the surface molecules, liquids contract to form a shape that minimizes the number...
27.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparison of ultrasound contrast agent production by sonication and mechanical agitation.

Ultrasonics sonochemistry·2026
Same author

Subharmonics are not an infallible safety metric for cavitation dynamics.

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·2026
Same author

Ultrasound-Triggered Gelation for Restoring Biomechanical Properties of Degenerated Functional Spinal Units.

Advanced healthcare materials·2025
Same author

Decade effects in mental addition.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2025
Same author

A Metric and Method for Calculating Energy-Preserving Spatiotemporal Cavitation Dose: Cavitational Radiated Energy Density (CRED).

IEEE transactions on bio-medical engineering·2025
Same author

Size matters: Micro- versus nanobubbles in ultrasound imaging and therapy.

Science advances·2025
Same journal

Synergistic Visible-Light-Driven CO<sub>2</sub> Reduction and H<sub>2</sub>O Oxidation over Ti<sub>3</sub>C<sub>2</sub> Quantum Dot-Modified Cu/g-C<sub>3</sub>N<sub>4</sub> Photocatalysts.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

Spontaneous Phase Separation Enables Rapid, Polymerization-Free Fabrication of Gels.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

Lamellar-Confinement-Induced ZIF-67 Nanosheet Mixed Matrix Membranes for Enhanced CH<sub>4</sub>/N<sub>2</sub> Separation.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

Structure Control of Oblate Nanoparticles Self-Assembled by ABC Cyclic Terpolymers under Soft Confinement.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

Tuning Brønsted/Lewis Acid Site Ratios via Ammonia Modulation for Selective Conversion of Glycerol to 1,3-Propanediol or Solketal.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

Catalytic and Nitriding Competition of Nitrogen Atom on Graphene and Its Finite Rate Surface Chemistry Model.

Langmuir : the ACS journal of surfaces and colloids·2026
See all related articles

Related Experiment Video

Updated: Jun 9, 2025

Induction of Microstreaming by Nonspherical Bubble Oscillations in an Acoustic Levitation System
08:19

Induction of Microstreaming by Nonspherical Bubble Oscillations in an Acoustic Levitation System

Published on: May 9, 2021

2.1K

Behavior of Microbubbles on Air-Aqueous Interfaces.

Hyunhong J Min1, Luca Bau1, Stephen J Payne2

  • 1Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford OX3 7LD, U.K.

Langmuir : the ACS Journal of Surfaces and Colloids
|October 25, 2024
PubMed
Summary
This summary is machine-generated.

Lipid-coated microbubbles show promise as a novel replacement for animal-derived lung surfactants, significantly reducing surface tension. This innovation could improve treatments for neonatal Respiratory Distress Syndrome (nRDS).

More Related Videos

A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)&#8211;Cell Interaction and the Resultant Bioeffects at the Single-cell Level
11:14

A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level

Published on: January 10, 2017

11.7K
Manufacture of Concentrated, Lipid-based Oxygen Microbubble Emulsions by High Shear Homogenization and Serial Concentration
13:17

Manufacture of Concentrated, Lipid-based Oxygen Microbubble Emulsions by High Shear Homogenization and Serial Concentration

Published on: May 26, 2014

15.0K

Related Experiment Videos

Last Updated: Jun 9, 2025

Induction of Microstreaming by Nonspherical Bubble Oscillations in an Acoustic Levitation System
08:19

Induction of Microstreaming by Nonspherical Bubble Oscillations in an Acoustic Levitation System

Published on: May 9, 2021

2.1K
A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)&#8211;Cell Interaction and the Resultant Bioeffects at the Single-cell Level
11:14

A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level

Published on: January 10, 2017

11.7K
Manufacture of Concentrated, Lipid-based Oxygen Microbubble Emulsions by High Shear Homogenization and Serial Concentration
13:17

Manufacture of Concentrated, Lipid-based Oxygen Microbubble Emulsions by High Shear Homogenization and Serial Concentration

Published on: May 26, 2014

15.0K

Area of Science:

  • Biomaterials Science
  • Neonatal Medicine
  • Surface Chemistry

Background:

  • Animal-derived lung surfactants are critical for treating neonatal Respiratory Distress Syndrome (nRDS) but face challenges like high cost and limited accessibility.
  • Existing surfactants are often ineffective when nebulized, necessitating research into alternative delivery methods and formulations.
  • A need exists for cost-effective, accessible, and nebulization-compatible lung surfactant replacements.

Purpose of the Study:

  • To investigate lipid-coated microbubbles as a potential alternative to animal-derived exogenous lung surfactants.
  • To evaluate the surface tension-reducing properties of different microbubble formulations.
  • To explore the mechanisms behind the surface tension reduction by microbubbles.

Main Methods:

  • Preparation of three distinct microbubble formulations using DPPC, with/without PEG40-stearate, and poractant alfa.
  • Measurement of equilibrium and dynamic surface tensions using a Langmuir-Blodgett trough on clean air-saline and simulated lung fluid interfaces.
  • Comparison of microbubble performance against equivalent lipid suspensions and a commercial surfactant (poractant alfa).

Main Results:

  • Microbubbles significantly reduced minimum surface tension compared to lipid suspensions and poractant alfa (e.g., PEG-free microbubbles achieved 4.3 mN/m vs. 20.4 mN/m for suspension).
  • Two mechanisms contributing to surface tension reduction were identified: foam fragmentation and microbubble clustering disrupting the phospholipid monolayer.
  • The dominant surface tension reduction mechanism was formulation and environment-dependent.

Conclusions:

  • Lipid-coated microbubbles demonstrate significant potential as replacements for exogenous lung surfactants.
  • The observed reduction in surface tension suggests a promising therapeutic avenue for nRDS.
  • Further in vivo studies are required to validate the efficacy of microbubble-based lung surfactants.