Related Experiment Video

Updated: Jun 9, 2025

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
03:45

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

3.0K

Association between cardiovascular risk factors and dilated and hypertrophic cardiomyopathy: Mendelian randomization

Chenchao Zou1, Huaxi Zou2, Ying Jiang2

  • 1Department of Cardiac Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006, China; Department of Cardiac Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006, China.

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
|October 25, 2024
PubMed

Insights

Smoking and obesity are causally linked to an increased risk of dilated cardiomyopathy. This genetic study provides new insights into heart failure causes.

Area of Science:

  • Cardiovascular Genetics
  • Epidemiology
  • Mendelian Randomization

Background:

  • Dilated cardiomyopathy (DCM) is a primary cause of heart failure.
  • Hypertrophic cardiomyopathy (HCM) is a leading cause of sudden cardiac death in young adults.
  • Observational studies on cardiovascular risk factors (smoking, alcohol, obesity) and cardiomyopathies are limited and prone to bias.

Purpose of the Study:

  • To investigate the causal associations between common cardiovascular risk factors and dilated and hypertrophic cardiomyopathies using a Mendelian randomization approach.
  • To leverage large-scale genetic data for robust causal inference.

Main Methods:

  • A two-sample Mendelian randomization analysis was conducted.
  • Genetic variants for body mass index, smoking, and alcohol consumption served as instrumental variables.
  • Genome-wide association study (GWAS) meta-analysis data from European populations were utilized for DCM (355,318 samples) and HCM (489,727 samples).

Main Results:

  • A genetic predisposition for smoking showed a significant association with an increased risk of dilated cardiomyopathy (OR = 1.33; 95% CI: 1.07-1.67).
  • A genetic predisposition for obesity was significantly associated with an increased risk of dilated cardiomyopathy (OR = 1.62; 95% CI: 1.30-2.02).
  • No significant associations were found for other investigated risk factors or for hypertrophic cardiomyopathy.

Conclusions:

  • This study provides evidence for a causal relationship between smoking and obesity and an elevated risk of developing dilated cardiomyopathy.
  • Findings highlight smoking and obesity as significant modifiable risk factors for dilated cardiomyopathy.
Abstract

Keywords:
AlcoholDilated cardiomyopathyHypertrophic cardiomyopathyMendelian randomization analysisObesitySmoking

More Related Videos

An Approach to Study Shape-Dependent Transcriptomics at a Single Cell Level06:02

An Approach to Study Shape-Dependent Transcriptomics at a Single Cell Level

Published on: November 2, 2020

5.7K
Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents07:26

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents

Published on: July 14, 2021

5.0K

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
1
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
3
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
1
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1