Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

486
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
486
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

4.9K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
4.9K
The Tumor Microenvironment02:17

The Tumor Microenvironment

6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

67.4K
Overview
67.4K
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

853
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
853
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

3.1K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A glucocorticoid-FAS axis controls immune evasion during metastatic seeding.

Nature·2026
Same author

Dietary cysteine enhances intestinal stemness via CD8<sup>+</sup> T cell-derived IL-22.

Nature·2025
Same author

Mammary intraepithelial lymphocytes and intestinal inputs shape T cell dynamics in lactogenesis.

Nature immunology·2025
Same author

Early Dynamics of Circulating Tumor HPV-DNA with Neoadjuvant Chemotherapy and Response-Adapted De-escalation in Human Papillomavirus-Associated Oropharyngeal Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research·2025
Same author

Multimodal Spatial Profiling Reveals Immune Suppression and Microenvironment Remodeling in Fallopian Tube Precursors to High-Grade Serous Ovarian Carcinoma.

Cancer discovery·2024
Same author

Multimodal Spatial Profiling Reveals Immune Suppression and Microenvironment Remodeling in Fallopian Tube Precursors to High-Grade Serous Ovarian Carcinoma.

bioRxiv : the preprint server for biology·2024
Same journal

Escaping the trap.

Nature reviews. Cancer·2026
Same journal

A genomic and epigenomic lens into the biology of acute lymphoblastic leukaemia.

Nature reviews. Cancer·2026
Same journal

Systemic health impact of cancer-associated extracellular vesicles and particles.

Nature reviews. Cancer·2026
Same journal

Imaging the hallmarks of cancer.

Nature reviews. Cancer·2026
Same journal

CLIM-TIME links tumour genetics to spatial immune architecture.

Nature reviews. Cancer·2026
Same journal

Serving sulfur to boost anti-tumour immunity.

Nature reviews. Cancer·2026
See all related articles

Related Experiment Video

Updated: Jun 9, 2025

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
09:01

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Published on: March 7, 2025

296

Stemness in solid malignancies: coping with immune attack.

Judith Agudo1,2,3,4,5, Yuxuan Miao6,7

  • 1Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA. judith_agudo@dfci.harvard.edu.

Nature Reviews. Cancer
|October 25, 2024
PubMed
Summary
This summary is machine-generated.

Cancer stem cells (CSCs) resist immunotherapy by evading immune detection, leading to relapse. New therapies must target CSCs to ensure effective cancer treatment and prevent recurrence.

More Related Videos

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice
07:36

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice

Published on: June 12, 2021

6.4K
Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis
07:45

Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis

Published on: January 26, 2024

1.8K

Related Experiment Videos

Last Updated: Jun 9, 2025

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
09:01

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Published on: March 7, 2025

296
Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice
07:36

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice

Published on: June 12, 2021

6.4K
Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis
07:45

Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis

Published on: January 26, 2024

1.8K

Area of Science:

  • Oncology
  • Immunology
  • Cancer Stem Cell Biology

Background:

  • Immunotherapy is a cornerstone of cancer treatment, necessitating understanding of immune evasion mechanisms.
  • Tumors exhibit cellular heterogeneity, often driven by cancer stem cells (CSCs) with stem cell-like properties.
  • CSCs possess self-renewal and differentiation capabilities, alongside remarkable resistance to immune responses.

Purpose of the Study:

  • To review how CSCs in solid tumors develop immune evasion strategies.
  • To explore how malignant transformation of tissue stem cells activates immune evasion.
  • To discuss CSCs' hijacking of normal stem cell features to resist immunity in advanced disease.

Main Methods:

  • Literature review focusing on CSC-specific immune evasion in solid tumors.
  • Analysis of mechanisms by which tissue stem cells activate immune evasion during oncogenesis.
  • Examination of CSC interactions with immune cells and their resistance strategies.

Main Results:

  • CSCs employ unique immune-evasive mechanisms that drive tumor regrowth and treatment relapse.
  • Malignant transformation activates intrinsic immune evasion and promotes interactions with suppressive immune cells.
  • Advanced stage CSCs utilize normal stem cell features to resist anti-tumor immunity.

Conclusions:

  • Current immunotherapies often fail due to overlooking CSC-specific immune evasion.
  • Targeting CSCs is crucial for overcoming cancer relapse and improving treatment efficacy.
  • Future immunotherapies should be designed to eliminate CSCs for durable cancer remission.