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Puerperal lactation suppression and prolactin.

H De Gezelle, M Dhont, M Thiery

    Acta Obstetricia Et Gynecologica Scandinavica
    |January 1, 1979
    PubMed
    Summary
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    Bromocriptine and stilbestrol effectively inhibit puerperal lactation, with bromocriptine lowering prolactin and stilbestrol increasing it. Both pharmacologic methods proved superior to physical interventions for lactation suppression.

    Area of Science:

    • Reproductive Endocrinology
    • Pharmacology
    • Obstetrics

    Background:

    • Puerperal lactation inhibition is a common clinical challenge.
    • Various pharmacologic and physical methods exist for managing lactation.
    • Understanding the efficacy and hormonal impact of different treatments is crucial.

    Purpose of the Study:

    • To compare the effectiveness of five different puerperal lactation inhibition methods.
    • To assess the impact of these treatments on prolactin plasma concentrations.
    • To identify optimal strategies for preventing postpartum lactation.

    Main Methods:

    • A randomized study involving 90 women divided into five groups.
    • Pharmacologic treatments included oral stilbestrol, oral bromocriptine, a diuretic compound (bendroflumethazide), and an injectable estrogen-testosterone combination.

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  • Control group received physical methods (breast support, infra-red waves).
  • Prolactin levels were monitored daily for five days.

    • Main Results:

    • Bromocriptine reduced prolactin levels; stilbestrol augmented them.
    • Both bromocriptine and stilbestrol demonstrated equal effectiveness in preventing lactation.
    • Diuretic and steroid injection treatments were less effective than bromocriptine/stilbestrol but superior to physical methods.
    • Prolactin levels correlated with clinical lactation inhibition outcomes.

    Conclusions:

    • Bromocriptine and stilbestrol are highly effective for puerperal lactation inhibition.
    • Pharmacologic interventions offer superior lactation suppression compared to physical methods.
    • Hormonal changes (prolactin) are key indicators of treatment efficacy.