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The Influence of Microbiota on Breast Cancer: A Review
Cara-Xenia-Rafaela Neagoe1, Mihaela Ionică2,3,4, Octavian Constantin Neagoe2,3,4
1Doctoral School, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania.
Cancers
|October 26, 2024
Summary
Alterations in the microbiota are increasingly linked to breast cancer. This review explores the microbiota
Area of Science:
- Oncology
- Microbiology
- Immunology
Background:
- Breast cancer is a leading cause of death in women globally.
- Emerging evidence links alterations in the microbiota to breast cancer development and progression.
- The tumor microenvironment (TME) and tumor immune microenvironment (TIME) are significantly influenced by the microbiota.
Purpose of the Study:
- To review the intricate relationship between microbiotas and breast cancer.
- To analyze the microbiota's impact on tumor growth, invasion, metastasis, drug resistance, and immune evasion.
- To investigate microbial profiles across breast cancer subtypes and compare tumor vs. normal tissues.
Main Methods:
- Comprehensive literature review of studies on breast cancer and microbiota.
- Analysis of microbiota's role in TME and TIME.
- Examination of microbial profiles in different breast cancer molecular subtypes.
Main Results:
- The microbiota is present in healthy breast tissue and changes during cancer progression.
- Microbiota significantly influences breast cancer hallmarks, including immune system evasion.
- Distinct microbial signatures are associated with different breast cancer subtypes.
Conclusions:
- Microbiotas show potential as diagnostic and prognostic biomarkers for breast cancer.
- Microbiota-based therapies offer novel strategies for breast cancer management.
- Further research is crucial to harness the microbiota's potential in breast cancer prevention, diagnosis, and treatment.
Keywords:
breast cancermicrobial signaturesmicrobiomemicrobiotatumor immune microenvironmenttumor microenvironmentMore Related Videos
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