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Related Experiment Video

Updated: Mar 29, 2026

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening
08:14

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening

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MicroRNAs in Breast Cancer: Diagnostic and Prognostic Potential, Challenges, and Clinical Reliability.

Cara-Xenia-Rafaela Neagoe1,2,3, Maximilian Gundershausen2, Mihaela Ionică2,3,4

  • 1Doctoral School, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania.

Biomedicines
|March 28, 2026
PubMed
Summary

Circulating microRNAs (miRNAs) show promise as non-invasive biomarkers for real-time breast cancer monitoring. Standardization of methods is crucial for their clinical adoption in diagnosis and outcome prediction.

Keywords:
breast cancercancer metastasiscancer proliferationdiagnostic biomarkersdrug resistanceliquid biopsymiRNAprognostic biomarkerstherapeutic targets

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Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization
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Area of Science:

  • Oncology
  • Molecular Biology
  • Biomarker Discovery

Background:

  • Precision medicine in breast cancer lacks real-time, non-invasive tumor monitoring tools.
  • Circulating microRNAs (miRNAs) are stable, reflecting molecular changes, making them ideal liquid biopsy biomarkers.
  • Current breast cancer management needs improved methods for tracking tumor dynamics and therapeutic response.

Purpose of the Study:

  • To review the current state of microRNA research in breast cancer.
  • To assess the utility of circulating miRNAs in early diagnosis and outcome prediction.
  • To highlight key miRNA targets (e.g., miR-21, miR-155, miR-200 family) and their dysregulation in breast cancer subtypes.

Main Methods:

  • Literature review of current microRNA research in breast cancer.
  • Analysis of specific miRNA targets and their diagnostic/prognostic potential.
  • Evaluation of challenges and requirements for clinical translation.

Main Results:

  • Specific miRNAs (miR-21, miR-155, miR-200 family) are consistently dysregulated across breast cancer subtypes.
  • Circulating miRNAs offer advantages over protein markers for monitoring tumor progression and resistance.
  • Technical inconsistencies (RNA isolation, normalization) hinder clinical reproducibility.

Conclusions:

  • Circulating miRNAs hold significant potential as non-invasive breast cancer biomarkers.
  • Standardized protocols and reliable reference genes are essential for clinical validation.
  • Large-scale prospective studies and international collaborations are needed for real-world implementation and routine oncological decision-making.