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Related Experiment Video

Updated: Jun 9, 2025

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro

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Genetics of Calcific Aortic Stenosis: A Systematic Review.

Vassilios S Vassiliou^1,2, Nicholas Johnson¹, Kenneth Langlands³

¹Norwich Medical School, University of East Anglia, Norwich NR4 7TJ, UK.

|October 26, 2024

Summary

Genetic factors significantly contribute to calcific aortic stenosis (CAS), the most common heart valve disease. Identifying these genetic associations aids risk stratification and enables targeted therapies for CAS prevention.

Keywords:

aortic stenosis calcific

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Published on: February 4, 2021

Area of Science:

Cardiovascular Genetics
Valvular Heart Disease Research
Molecular Medicine

Background:

Calcific aortic stenosis (CAS) is the most common valvular heart disease in Western populations.
Associated risk factors include advanced age, male sex, hypertension, diabetes, and impaired renal function.
This review synthesizes current literature on genetic associations with CAS.

Conclusions:

Numerous genetic associations contribute to the development of calcific aortic stenosis.
Recognizing these genetic links can improve risk stratification for patients and their families, facilitating targeted screening.
Understanding these genetic factors is crucial for developing novel, targeted therapeutic interventions and potential gene therapies for CAS.