Presepsin Does Not Predict Risk of Death in Sepsis Patients Admitted to the Intensive Care Unit: A Prospective...

Area of Science:

• Critical Care Medicine
• Infectious Diseases
• Biomarker Research

Background:

• Sepsis is a life-threatening condition characterized by organ dysfunction due to dysregulated host response to infection.
• Early identification of sepsis severity and source is crucial for patient outcomes.
• Biomarkers like presepsin (P-SEP) are investigated for their prognostic value in sepsis.

Purpose of the Study:

• To assess the predictive utility of presepsin (P-SEP) for mortality risk in intensive care unit (ICU) sepsis patients at admission.
• To compare P-SEP with other inflammatory markers (CRP, PCT, IL-6) in predicting sepsis outcomes.
• To evaluate P-SEP's ability to predict the presence of a microbiological infection focus.

Main Methods:

• Adult patients meeting SEPSIS-3 criteria upon ICU admission were enrolled.
• Demographic, clinical data, and inflammatory markers (P-SEP, CRP, PCT, IL-6) were collected.
• Primary endpoint: in-hospital mortality. Secondary endpoint: positive microbiological test results.

Main Results:

• No significant difference in P-SEP, CRP, PCT, or IL-6 levels was observed between survivors and non-survivors.
• These markers did not accurately predict mortality risk via ROC analysis.
• P-SEP, PCT, CRP, and IL-6 were significantly elevated in patients with confirmed microbiological infection.

Conclusions:

• Presepsin (P-SEP) is not a reliable predictor of in-hospital mortality in ICU sepsis patients.
• Presepsin demonstrates utility in predicting the presence of a positive microbiological culture in sepsis patients.