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Related Concept Videos

Rabies01:28

Rabies

Rabies is a lethal zoonotic disease caused by a single-stranded, negative-sense RNA virus of the Lyssavirus genus, within the family Rhabdoviridae. Its primary mode of transmission to humans is through bites or saliva-contaminated scratches from infected mammals such as dogs, bats, raccoons, or foxes. Transmission can also occur if infectious saliva contacts abraded skin or intact mucous membranes, including the conjunctiva.Viral Entry and Early ReplicationOnce introduced at the bite or scratch...

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In Vitro ELISA Test to Evaluate Rabies Vaccine Potency
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Clinical Pathology Evaluation in Pet Rabbits Vaccinated Against Rabbit Hemorrhagic Disease Virus 2 (RHDV2).

Chris Griffin1, Salina Locke2, Fabiano Montiani-Ferreira3,4

  • 1Griffin Avian & Exotic Veterinary Hospital, Kannapolis, NC 28083, USA.

Animals : an Open Access Journal From MDPI
|October 26, 2024
PubMed
Summary
This summary is machine-generated.

A new recombinant vaccine for rabbit hemorrhagic disease virus 2 (RHDV2) shows promise, inducing significant antibody increases post-vaccination. However, variable responses and waning immunity highlight the need for further RHDV2 vaccine studies.

Keywords:
ELISARHDV2antibodybiochemistryhematologylagomorph

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Area of Science:

  • Veterinary Medicine
  • Immunology
  • Virology

Background:

  • Rabbit hemorrhagic disease virus 2 (RHDV2) is a highly pathogenic virus that emerged in the US in 2018.
  • An RHDV2 recombinant vaccine received emergency use authorization in the US.
  • The efficacy and safety of this RHDV2 vaccine in pet rabbits require further investigation.

Purpose of the Study:

  • To assess the safety and immunogenicity of a recombinant RHDV2 vaccine in pet rabbits.
  • To monitor antibody levels and clinical signs following vaccination and booster doses.
  • To evaluate the duration of protective antibody levels in vaccinated rabbits.

Main Methods:

  • Physical examinations and clinical pathology tests were performed on 29 pet rabbits post-vaccination.
  • Antibody levels were measured at baseline, day 21 (post-initial), and day 49 (post-booster).
  • A subset of rabbits was assessed 11-12 months post-initial vaccination to determine long-term antibody levels.

Main Results:

  • No vaccine-related physical abnormalities were observed by owners or clinicians.
  • Antibody levels significantly increased at days 21 and 49 compared to baseline (p < 0.0001).
  • Variable seroconversion and lower responses were noted in older rabbits; antibody levels at 11-12 months were not significantly different from baseline (p = 0.21).

Conclusions:

  • The RHDV2 vaccine is safe and elicits an initial immune response in pet rabbits.
  • Variability in antibody response and potential waning immunity necessitate further research.
  • Additional studies are required to optimize RHDV2 vaccine protocols and understand the duration of protection.