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Prospecting Microbial Strains for Bioremediation and Probiotics Development for Metaorganism Research and Preservation

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Published on: October 31, 2019

Probio-Ichnos: A Database of Microorganisms with In Vitro Probiotic Properties.

Margaritis Tsifintaris¹, Despoina Eugenia Kiousi¹, Panagiotis Repanas¹

¹Department of Molecular Biology and Genetics, Democritus University of Thrace, 68100 Alexandroupolis, Greece.

|October 26, 2024

Summary

This summary is machine-generated.

Probio-ichnos is a new database detailing microbial strains with in vitro probiotic properties. It organizes data on strain characteristics and whole-genome sequences to aid research on beneficial microbes.

Keywords:

adhesion antimicrobial activity antioxidant capacity antiproliferation database immunomodulation in vitro properties probiotics strain specificity

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Published on: July 31, 2019

Area of Science:

Microbiology
Bioinformatics
Food Science

Background:

Probiotics are live microorganisms conferring health benefits by regulating host homeostasis.
Lactic acid bacteria (LAB), yeasts, and Bacillus species are common probiotic examples.
Existing literature lacks a centralized, curated resource for in vitro probiotic strain data.

Purpose of the Study:

To introduce Probio-ichnos, the first manually curated database of microbial strains with in vitro probiotic characteristics.
To consolidate and present comprehensive information on strain properties derived from diverse sources.
To facilitate research by enabling targeted validation and comparative analysis of probiotic strains.

Main Methods:

Systematic literature search of PubMed using the keyword 'probiotic'.
Manual filtering of 27,715 studies to identify 2207 relevant publications with in vitro experimental data.
Data extraction on strain-specific probiotic attributes (e.g., acid/bile resistance, antimicrobial activity) and whole-genome sequence availability.

Main Results:

The Probio-ichnos database contains 12,993 entries on in vitro probiotic characteristics.
Data covers 11,202 distinct strains across 470 species and 143 genera.
Information is presented using binary categorization of probiotic attributes and includes whole-genome sequence availability.

Conclusions:

Probio-ichnos provides a valuable, literature-based resource for researchers studying probiotics.
The database streamlines access to in vitro probiotic data, supporting strain selection and validation.
It aims to accelerate the discovery and application of beneficial microbial strains.