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Tracking the Risk of Cardiovascular Disease after Almond and Oat Milk Intervene or Statin Medication with a Powerful
Chia-Hsuan Cheng1,2, Hiromi Yatsuda1,2, Han-Hsiang Chen3
1Graduate School of Science and Technology, Shizuoka University, 3-5-1 Johoku, Naka-ku, Hamama-tsu-shi 432-8561, Japan.
Insights
A new point-of-care test (POCT) for apolipoprotein B (ApoB) using a shear horizontal surface acoustic wave (SH-SAW) platform effectively monitors cardiovascular disease (CVD) risk. Both almond/oat milk and statin interventions significantly lowered ApoB levels.
Area of Science:
- Biomedical Engineering
- Cardiovascular Medicine
- Point-of-Care Diagnostics
Background:
- Cardiovascular disease (CVD) is a leading global cause of mortality.
- Early detection and monitoring of lipid status are crucial for high-risk individuals.
- Current hospital-based lipid measurements require large optical detection machines, necessitating point-of-care testing (POCT) for effective CVD monitoring.
Purpose of the Study:
- To develop a novel POCT approach for apolipoprotein B (ApoB) detection.
- To utilize a shear horizontal surface acoustic wave (SH-SAW) platform for assessing heart disease risk.
- To evaluate the efficacy of interventions on ApoB levels using the developed POCT.
Main Methods:
- Development of a reflective SH-SAW sensor to minimize device size and amplify signals.
- Application of the SH-SAW platform for monitoring ApoB levels.
- Assessment of changes in ApoB levels following a four-week intervention with almond/oat milk or statins.
Main Results:
- The SH-SAW ApoB test demonstrated a linear range of 0-212 mg/dL with a high coefficient of correlation (R=0.9912).
- Both almond/oat milk and statin interventions led to significant reductions in ApoB levels (-23.3% and -53.1%, respectively; p < 0.05 and p < 0.01).
Conclusions:
- The SH-SAW POCT device shows promise as a valuable tool for monitoring CVD risk.
- This technology can facilitate frequent monitoring during routine follow-up visits.
- The study validates the impact of lifestyle and pharmacological interventions on ApoB levels.
Abstract:
Cardiovascular disease (CVD) represents the leading cause of death worldwide. For individuals at elevated risk for cardiovascular disease, early detection and monitoring of lipid status is imperative. The majority of lipid measurements conducted in hospital settings employ optical detection, which necessitates the use of relatively large-sized detection machines. It is, therefore, necessary to develop point-of-care testing (POCT) for lipoprotein in order to monitor CVD. To enhance the management and surveillance of CVD, this study sought to develop a POCT approach for apolipoprotein B (ApoB) utilizing a shear horizontal surface acoustic wave (SH-SAW) platform to assess the risk of heart disease. The platform employs a reflective SH-SAW sensor to reduce the sensor size and enhance the phase-shifted signals. In this study, the platform was utilized to monitor the impact of a weekly almond and oat milk or statins intervention on alterations in CVD risk. The SH-SAW ApoB test exhibited a linear range of 0 to 212 mg/dL, and a coefficient correlation (R) of 0.9912. Following a four-week intervention period, both the almond and oat milk intervention (-23.3%, p < 0.05) and statin treatment (-53.1%, p < 0.01) were observed to significantly reduce ApoB levels. These findings suggest that the SH-SAW POCT device may prove a valuable tool for monitoring CVD risk, particularly during routine daily or weekly follow-up visits.
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