Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A macin family antimicrobial peptide from Atrina pectinata exhibiting dual functions in direct bactericidal activity and hemocyte immune modulation.

Fish & shellfish immunology·2026
Same author

Vanadium-Induced Lattice Compression and Electronic Modulation in Iridium-Ruthenium Electrocatalysts Boost Acidic Oxygen Evolution Reaction.

Journal of the American Chemical Society·2026
Same author

Dual resistance to carbapenems and colistin in <i>Enterobacter</i>: Taiwan surveillance of antimicrobial resistance, 2010-2020.

Emerging microbes & infections·2026
Same author

Engineered self-driven intelligent nanomachine induced by target-mediated knock-on effect to determine attomolar nucleic acids.

Talanta·2025
Same author

Handheld Lab-on-a-Chip System for Label-Free Dual-Plex Detection of Biomarkers Through On-Chip Plasma Separation.

Biosensors·2025
Same author

Areca nut extract exposure disrupts myogenesis and metabolism in C2C12 cells.

Current research in toxicology·2025
Same journal

RETRACTED: Zhang et al. A Novel Framework for Reconstruction and Imaging of Target Scattering Centers via Wide-Angle Incidence in Radar Networks. <i>Sensors</i> 2025, <i>25</i>, 6802.

Sensors (Basel, Switzerland)·2026
Same journal

Enhancing Unsupervised Multi-Source Domain Adaptation for Person Re-Identification via Mixture of Experts and Graph-Based Relation.

Sensors (Basel, Switzerland)·2026
Same journal

Development of an Instrumented Glove for Palmar Pressure Assessment in Kayakers.

Sensors (Basel, Switzerland)·2026
Same journal

Development and Experimental Validation of an Autonomous IoT-Based Monitoring System for Real-Time Water Quality Assessment in the Amazon River.

Sensors (Basel, Switzerland)·2026
Same journal

Semi-Supervised Adversarial Learning Framework for Controller Area Network Bus Intrusion Detection.

Sensors (Basel, Switzerland)·2026
Same journal

Smart Optimization Method for Safety Signs in Innovative Manufacturing Environments Integrating Industrial Field IoT Sensors and Knowledge Graphs.

Sensors (Basel, Switzerland)·2026
See all related articles

Related Experiment Video

Updated: Jun 9, 2025

A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis
14:53

A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis

Published on: September 10, 2014

17.1K

Blood Biomarker Detection Using Integrated Microfluidics with Optical Label-Free Biosensor.

Chiung-Hsi Li1, Chen-Yuan Chang1, Yan-Ru Chen1

  • 1Department of Mechanical Engineering, National Yang Ming Chiao Tung University, Hsinchu 30010, Taiwan.

Sensors (Basel, Switzerland)
|October 26, 2024
PubMed
Summary
This summary is machine-generated.

This study presents an optofluidic chip for simultaneous blood plasma separation and label-free albumin detection. The integrated device enables efficient biomarker analysis for point-of-care applications.

Keywords:
guided-mode resonancelab-on-a-chipoptical biosensoroptofluidics

More Related Videos

Detection of Human Leukocyte Antigen Biomarkers in Breast Cancer Utilizing Label-free Biosensor Technology
08:27

Detection of Human Leukocyte Antigen Biomarkers in Breast Cancer Utilizing Label-free Biosensor Technology

Published on: March 24, 2015

14.7K
Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation
13:42

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Published on: September 19, 2017

11.7K

Related Experiment Videos

Last Updated: Jun 9, 2025

A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis
14:53

A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis

Published on: September 10, 2014

17.1K
Detection of Human Leukocyte Antigen Biomarkers in Breast Cancer Utilizing Label-free Biosensor Technology
08:27

Detection of Human Leukocyte Antigen Biomarkers in Breast Cancer Utilizing Label-free Biosensor Technology

Published on: March 24, 2015

14.7K
Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation
13:42

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Published on: September 19, 2017

11.7K

Area of Science:

  • Optofluidics
  • Biomedical Engineering
  • Analytical Chemistry

Background:

  • Accurate and rapid detection of biomarkers like albumin is crucial for clinical diagnostics.
  • Existing methods for plasma separation and biomarker detection can be complex and time-consuming.
  • Point-of-care testing requires integrated devices for simplified sample processing and analysis.

Purpose of the Study:

  • To develop an integrated optofluidic chip for simultaneous blood plasma separation and label-free albumin detection.
  • To demonstrate the chip's capability for sensitive and specific biomarker quantification.
  • To assess the potential of the device for point-of-care clinical applications.

Main Methods:

  • Development of an optofluidic chip integrating a microfluidic system with a guided-mode resonance (GMR) sensor.
  • Incorporation of a sedimentation chamber for density-based plasma separation.
  • Fabrication of the GMR sensor using plastic replica molding and functionalization with antibodies for albumin detection.

Main Results:

  • The optofluidic chip successfully achieved simultaneous plasma separation and label-free albumin detection.
  • The GMR sensor demonstrated a high bulk sensitivity of 175.66 nm/RIU.
  • A limit of detection of 0.16 μg/mL for recombinant albumin was achieved with antibody functionalization.

Conclusions:

  • The integrated optofluidic chip offers a promising platform for efficient biomarker detection.
  • The device facilitates sensitive and label-free analysis, suitable for point-of-care settings.
  • This technology has significant potential for advancing clinical diagnostics and personalized medicine.