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Bidirectional influence between benign prostatic hyperplasia, prostate cancer, and prostatitis and mental disorders:
Xiangyu Chen1, Congzhe Ren1, Qihua Wang1
1Department of Urology, Tianjin Medical University General Hospital, Tianjin, China.
Summary
This study used Mendelian randomization to investigate causal links between major mental disorders and prostate conditions. Insomnia and mood disorders may increase benign prostatic hyperplasia risk, while ADHD shows a potential link to prostate cancer risk.
Area of Science:
- Genetics and Epidemiology
- Mental Health Research
- Urology and Oncology
Background:
- Investigating potential causal relationships between major mental disorders (MDs) and common prostatic diseases, including benign prostatic hyperplasia (BPH), prostate cancer (PCa), and prostatitis.
- Understanding these links is crucial for developing integrated prevention and treatment strategies for both mental and urological health conditions.
Purpose of the Study:
- To employ Mendelian randomization (MR) to assess the potential causal effects of fifteen major mental disorders on the risk of developing BPH, PCa, and prostatitis.
- To identify specific mental disorders that may causally influence the incidence or progression of these prostate diseases.
Main Methods:
- Utilized Mendelian randomization, a robust genetic epidemiological method, to infer causality.
- The primary analytical approach involved the inverse variance-weighted (IVW) method for assessing the genetic associations.
- Examined associations between genetic variants for major mental disorders and outcomes for BPH, PCa, and prostatitis.
Main Results:
- Insomnia showed a significant association with increased BPH risk (OR, 1.6190; p=0.0017), and mood disorders showed a nominal association with increased BPH risk (OR, 1.1590; p=0.0221).
- Attention deficit hyperactivity disorder (ADHD) was suggestively associated with a reduced risk of prostate cancer (OR=0.9474; p=0.0058), but no causal link was found between PCa and MDs.
- Anorexia nervosa and depression were nominally associated with increased prostatitis risk, while prostatitis was suggestively associated with increased ADHD risk.
Conclusions:
- The study identified specific associations, such as insomnia and mood disorders with BPH risk, and potential links between certain mental disorders and prostatitis.
- These findings suggest potential etiological overlaps between mental health conditions and prostatic diseases, warranting further investigation.
- Provides a foundation for clinicians to develop targeted programs for the prevention and treatment of co-occurring mental and prostatic diseases.
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