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Association between inflammatory burden index and coronary slow flow phenomenon in patients with chest pain and no

Zhi-Gao Wen1, Jun-Jie Long2, Yong Wang3

  • 1Department of Emergency Medicine, Shenzhen Luohu Hospital Group Luohu People's Hospital, The Third Affiliated Hospital of Shenzhen University, Shenzhen, China. jzwenzhigao@163.com.

BMC Cardiovascular Disorders
|October 27, 2024
PubMed

Insights

The inflammatory burden index (IBI) may predict coronary slow flow phenomenon (CSFP) in patients with chest pain. Higher IBI levels indicate a greater risk of developing CSFP, improving diagnostic capabilities.

Area of Science:

  • Cardiology
  • Inflammation Biomarkers
  • Coronary Artery Disease

Background:

  • The inflammatory burden index (IBI) is a novel indicator associated with various diseases.
  • Few studies have explored the relationship between IBI and coronary slow flow phenomenon (CSFP).

Purpose of the Study:

  • To investigate the predictive value of IBI for CSFP in patients presenting with chest pain and no obstructive coronary artery disease.

Main Methods:

  • 1126 individuals with chest pain and no obstructive coronary arteries were included.
  • IBI was determined using plasma C-reactive protein, neutrophil, and lymphocyte counts.
  • A 1:2 age- and sex-matched control group was established.

Main Results:

  • IBI was significantly higher in the CSFP group (21.1 ± 6.5) compared to controls (14.5 ± 6.4).
  • IBI and body mass index were identified as independent predictors of CSFP.
  • An IBI cutoff of >15.74 showed 77.5% sensitivity and 67.6% specificity for CSFP (AUC = 0.799).

Conclusions:

  • IBI may serve as an independent predictor of CSFP in patients with chest pain and normal coronary arteries.
  • IBI can enhance the predictive value for CSFP beyond traditional indicators.
Abstract

Keywords:
Chest painCoronary slow flow phenomenonInflammatory burden indexNo obstructive coronary arteriesPredictors

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