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Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

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Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
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Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
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Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

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Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
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Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography FDG-PET/CT
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FDG PET/CT in large vessel vasculitis.

Karan Bir Singh1, Katherine Nguyen2,3, Anthony Sammel2,3

  • 1Department of Nuclear Medicine and PET, The Prince of Wales Hospital, Sydney, New South Wales, Australia.

Journal of Medical Imaging and Radiation Oncology
|October 27, 2024
PubMed
Summary
This summary is machine-generated.

Large vessel vasculitis (LVV) involves artery inflammation. Fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) offers a non-invasive, whole-body method for assessing this inflammation and related conditions.

Keywords:
FDG PET/CTgiant cell arteritislarge vessel vasculitispolymyalgia rheumaticarheumatology

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Area of Science:

  • Rheumatology
  • Nuclear Medicine
  • Vascular Medicine

Background:

  • Large vessel vasculitides (LVV) are immune-mediated inflammatory conditions affecting medium to large arteries.
  • Giant cell arteritis, Takayasu arteritis, and aortitis/periaortitis are key examples of LVV.
  • Non-specific clinical symptoms necessitate advanced diagnostic imaging for accurate diagnosis.

Purpose of the Study:

  • To review the clinical features of LVV and polymyalgia rheumatica.
  • To summarize the evidence supporting the use of FDG PET/CT in assessing LVV.
  • To provide practical guidance on FDG PET/CT for LVV diagnosis and management.

Main Methods:

  • Literature review of clinical presentations of LVV and polymyalgia rheumatica.
  • Systematic evaluation of studies utilizing FDG PET/CT for LVV assessment.
  • Development of recommendations for patient preparation, image acquisition, and interpretation.

Main Results:

  • FDG PET/CT is a powerful metabolic imaging tool for non-invasive, whole-body assessment of vascular inflammation.
  • Evidence supports FDG PET/CT's role in diagnosing and monitoring LVV.
  • Specific protocols enhance the utility of FDG PET/CT in this context.

Conclusions:

  • FDG PET/CT is a valuable diagnostic modality for large vessel vasculitis.
  • Comprehensive guidance is provided for optimizing FDG PET/CT use in clinical practice.
  • This imaging technique aids in the early and accurate diagnosis of LVV.