Related Experiment Video
Updated: Jun 9, 2025
07:33
Therapeutic Effectiveness of a Dietary Supplement for Management of Halitosis in Dogs
Published on: July 6, 2015
11.3K
Features of Idiopathic Halitosis and Its Association With Low-Grade Systemic Inflammation
Dan Ping Ruan1, Ye Kan Li1, Xiao Xian Qian2,3
1Department of Stomatology, Minhang Hospital, Fudan University, Shanghai, China.
Oral Diseases
|October 28, 2024
Summary
Idiopathic halitosis, a rare condition, is linked to low-grade systemic inflammation (LGSI). Fractional exhaled nitric oxide (FeNO200) shows high diagnostic power for this condition.
Area of Science:
- Medical Research
- Respiratory Medicine
- Inflammation Studies
Background:
- Idiopathic halitosis is an uncommon clinical finding with limited research.
- Understanding its underlying causes, particularly systemic inflammation, is crucial.
Purpose of the Study:
- To investigate the characteristics of idiopathic halitosis.
- To explore its potential association with low-grade systemic inflammation (LGSI).
Main Methods:
- Retrospective analysis of 54 idiopathic halitosis patients versus 63 healthy controls.
- Assessment of organoleptic scores (OLS), exhaled volatile sulfur compounds (VSCs), inflammatory cytokines, and fractional exhaled nitric oxide (FeNO200).
Main Results:
- Idiopathic halitosis patients exhibited elevated FeNO200 (79.63%) compared to controls (p < 0.001).
- FeNO200 levels correlated positively with OLS (r=0.871) and dimethyl sulfide (DMS) (r=0.485).
- Slight elevation in inflammatory cytokines was noted in a small subset of patients (5.56%).
Conclusions:
- Idiopathic halitosis is rare, associated with LGSI, and potentially linked to extraoral factors.
- FeNO200 demonstrates high sensitivity (79.63%) and specificity (100%) for diagnosing idiopathic halitosis.
- FeNO200 is recommended for diagnosing idiopathic halitosis due to its diagnostic power.
Related Concept Videos
01:17Irritable Bowel Syndrome I: Introduction
252
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
252
01:17Chronic Bowel Disorders: Introduction
394
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
394
01:23Chronic Pharyngitis
1.3K
Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
1.3K
01:30Inflammatory Bowel Disease II: Crohn's Disease
189
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
189
01:30Tonsillitis I: Introduction
211
Tonsillitis is inflammation of the tonsils, which are two lymphoid tissue masses at the back of the throat. This condition can cause discomfort and irritation in the throat.
Etiology
Three primary contributing factors have been identified.
Etiology
Three primary contributing factors have been identified.
211
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.7K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.7K