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Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
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Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
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Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
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Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
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Exploring the Potential Treatment for Mpox.

Kevin Kevin1, Robert Sinto, Leonard Nainggolan

  • 1Division of Tropical and Infectious Disease, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.. kingkevin2222@gmail.com.

Acta Medica Indonesiana
|October 28, 2024
PubMed
Summary
This summary is machine-generated.

Monkeypox (Mpox) antiviral therapies are crucial due to global spread. This review examines tecovirimat, brincidofovir, and cidofovir for treating mpox virus infections.

Keywords:
MpoxOrthopoxvirusTreatment

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Area of Science:

  • Virology
  • Infectious Diseases
  • Public Health

Background:

  • Monkeypox (Mpox) is a viral zoonosis presenting with smallpox-like symptoms.
  • Global spread of mpox has occurred since the 2022 outbreak, potentially linked to reduced vaccination.
  • Emerging monthly cases highlight the urgent need for effective mpox therapies.

Purpose of the Study:

  • To review the mechanisms of action, clinical use, and efficacy of key antiviral agents against the mpox virus.
  • To provide evidence supporting the use of antivirals in managing non-variola orthopoxvirus infections.

Main Methods:

  • Literature review of scientific articles and clinical trial data.
  • Analysis of existing research on tecovirimat, brincidofovir, and cidofovir.
  • Discussion of antiviral mechanisms and current clinical applications.

Main Results:

  • Tecovirimat, brincidofovir, and cidofovir demonstrate in vitro activity against the mpox virus.
  • These antivirals are currently used under expanded access protocols for non-variola orthopoxvirus infections.
  • Phase 3 clinical trials are ongoing to further establish efficacy and safety.

Conclusions:

  • Antiviral therapies are essential for managing the global mpox outbreak.
  • Tecovirimat, brincidofovir, and cidofovir represent promising treatment options, with ongoing research to confirm their clinical utility.