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Published on: December 11, 2013
Diet and exercise in relation to lower extremity artery disease
Aleš Blinc1,2, Kosmas I Paraskevas3, Agata Stanek4
1Department of Vascular Diseases, University Medical Center Ljubljana, Ljubljana, Slovenia - ales.blinc@kclj.si.
Adherence to the Mediterranean diet (MeD) may reduce peripheral arterial disease (PAD) risk. Combining healthy behaviors, including physical activity and diet, is key for preventing PAD and improving outcomes.
Area of Science:
- Cardiovascular Health
- Nutritional Science
- Exercise Physiology
Background:
- Mediterranean diet (MeD) adherence is linked to reduced peripheral arterial disease (PAD)/lower extremity arterial disease (LEAD) incidence in observational and randomized trials.
- MeD adherence shows potential for secondary prevention of major adverse cardiovascular events, though confirmation in larger trials is pending.
- The impact of vegetarian, vegan, or ketogenic diets on PAD/LEAD incidence and outcomes remains largely unknown.
Purpose of the Study:
- To review the current evidence on dietary patterns and physical activity in relation to peripheral arterial disease (PAD)/lower extremity arterial disease (LEAD).
- To explore the role of various diets and physical activity levels in the prevention and management of PAD/LEAD.
- To synthesize findings regarding the effectiveness of combined healthy behaviors for cardiovascular health and PAD/LEAD.
Main Methods:
- Literature review of observational trials and randomized controlled trials.
- Analysis of studies examining the relationship between diet, body mass index, physical activity, and PAD/LEAD.
- Synthesis of evidence on the prognostic value of nutritional status and the benefits of exercise interventions.
Main Results:
- Mediterranean diet (MeD) is associated with reduced PAD/LEAD incidence and improved cardiovascular outcomes.
- Abdominal obesity is linked to PAD/LEAD, but the lowest incidence is observed in overweight individuals (BMI 25-29.9 kg/m²).
- Habitual physical activity (PA) confers health benefits; lower exercise levels correlate with more prevalent PAD/LEAD. Supervised walking training is a recommended first-line treatment for intermittent claudication.
Conclusions:
- Combinations of healthy behaviors, including adherence to the Mediterranean diet and regular physical activity, are more effective in preventing PAD/LEAD than single components.
- Further research is needed to clarify the effects of specific diets (vegetarian, vegan, ketogenic) on PAD/LEAD.
- Lifestyle modifications, particularly diet and exercise, play a crucial role in the primary and secondary prevention of PAD/LEAD.
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