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Related Concept Videos

Heart Valves01:16

Heart Valves

The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
Thoracic Aorta01:15

Thoracic Aorta

The thoracic section of the aorta begins at the T5 vertebra and extends to the T12 level at the diaphragm, initially progressing through the mediastinum to the left of the spinal column. Throughout its course in the thoracic segment, the thoracic aorta emits various offshoots known collectively as visceral and parietal branches. The branches that predominantly supply blood to visceral organs are termed visceral branches and include bronchial, pericardial, esophageal, and mediastinal arteries,...
Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
Pleura of the Lungs01:13

Pleura of the Lungs

The lungs are nestled in a cavity, shielded by the pleura. The pleura, a form of serous membrane, wraps around each lung. This membrane arrangement consists of two layers: the visceral and parietal pleurae. The visceral pleura lines the surface of the lungIn contrast, the parietal pleura is the outer layer and contacts to the thoracic wall, the mediastinum, and the diaphragm. The hilum is the point of connection between the visceral and parietal layers. The space between the parietal and...
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
Pneumothorax II: Pathophysiology01:08

Pneumothorax II: Pathophysiology

Pneumothorax means the presence of air in the pleural space — the thin potential gap between the visceral and parietal pleura. This condition disrupts the normal pressure balance that keeps the lungs inflated, leading to partial or complete collapse of the affected lung.Normal physiologyUnder normal conditions, the pleural space maintains a slightly negative intrapleural pressure, which keeps the lungs expanded against the chest wall. This negative pressure creates a delicate balance between...

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Related Experiment Video

Updated: Jul 18, 2026

Implantation of Total Artificial Heart in Congenital Heart Disease
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Bilateral Pulmonary Arteriovenous Malformations: Challenges in a Rare and Complex Case.

Aayushi Joshi1, Vasu Saini1, Bhumika Bheemavarapu2

  • 1Pediatrics, Shri Guru Ram Rai Institute of Medical and Health Sciences, Dehradun, IND.

Cureus
|October 28, 2024
PubMed
Summary

Pulmonary arteriovenous malformations (PAVMs) can cause cyanosis in children. Endovascular treatment effectively closed multiple PAVMs in a young boy, resolving his symptoms.

Keywords:
congenital abnormalitiescongenital birth defectcongenital diseaseendovascular coil embolizationhereditary hemorrhagic telangiectasia (hht)pavmperioral cyanosispulmonary arteriovenous malformations

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Area of Science:

  • Vascular Surgery
  • Pediatric Cardiology
  • Interventional Radiology

Background:

  • Pulmonary arteriovenous malformations (PAVMs) are rare vascular anomalies connecting pulmonary arteries and veins.
  • PAVMs can lead to severe complications like paradoxical emboli, necessitating timely diagnosis and management in children.

Observation:

  • A five-year-old boy presented with persistent cyanosis and clubbing over eight months.
  • Imaging and angiography identified multiple, diffuse, bilateral PAVMs.

Findings:

  • The patient's PAVMs were successfully treated using an endovascular approach.
  • This intervention aimed to eliminate the abnormal vascular connections.

Implications:

  • Endovascular treatment is a viable option for complex PAVMs in pediatric patients.
  • Prompt management of PAVMs can prevent life-threatening embolic events and improve cyanosis.