Childhood amblyopia: A systematic review of recent management options

This study reviews the current information on treatment of childhood amblyopia, with the goal of improving visual functions. The authors searched various online databases including PubMed, Web of Science, ProQuest, Scopus, Google Scholar, Ebsco, and Medline. The articles, published between 2002 and 2023, included in this study were used to assess the different modalities for the management of different types of childhood amblyopia. The final systematic review included 41 studies from different countries, covering 4060 children with a mean age 6.8 ± 124 years. The findings showed that childhood amblyopia commonly treated through a systemic approach, i.e., starting with treatment of refractive errors with given optical adaptation time, followed by visually stimulating amblyopic eye by covering the dominant eye with patching, Atropine or Bangerter filters. Refractive adaptation period of 18-22 weeks has proven to show a significant improvement in visual acuity. It has been confirmed that 2 h patching is effective for the first time treated amblyopes, and if there is no improvement, increase the period to 6 h daily. Novel methods that improve binocular function such as dichoptic, perceptual training, video gaming, and drugs that facilitate visual neuroplasticity, are useful in the treatment of amblyopia that is not responsive to conventional therapy. The study concludes that significant evidence show that childhood amblyopia is treated through a systemic approach. Starting from correcting refractive errors with a period of optical adaptation, followed by patching therapy and atropine penalization. New methods that improve the binocular functions and medications that facilitate visual neuroplasticity have found to be useful in the treatment of amblyopia that is not responsive to conventional treatment.