Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

399
This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
On...
399
Model Approaches for Pharmacokinetic Data: Distributed Parameter Models01:06

Model Approaches for Pharmacokinetic Data: Distributed Parameter Models

60
Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
60
Mechanistic Models: Compartment Models in Individual and Population Analysis01:23

Mechanistic Models: Compartment Models in Individual and Population Analysis

29
Mechanistic models are utilized in individual analysis using single-source data, but imperfections arise due to data collection errors, preventing perfect prediction of observed data. The mathematical equation involves known values (Xi), observed concentrations (Ci), measurement errors (εi), model parameters (ϕj), and the related function (ƒi) for i number of values. Different least-squares metrics quantify differences between predicted and observed values. The ordinary least...
29
Pharmacokinetic Models: Comparison and Selection Criterion01:26

Pharmacokinetic Models: Comparison and Selection Criterion

46
Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
46
Parametric Survival Analysis: Weibull and Exponential Methods01:14

Parametric Survival Analysis: Weibull and Exponential Methods

367
Parametric survival analysis models survival data by assuming a specific probability distribution for the time until an event occurs. The Weibull and exponential distributions are two of the most commonly used methods in this context, due to their versatility and relatively straightforward application.
Weibull Distribution
The Weibull distribution is a flexible model used in parametric survival analysis. It can handle both increasing and decreasing hazard rates, depending on its shape parameter...
367
Multicompartment Models: Overview01:14

Multicompartment Models: Overview

104
Multicompartment models are mathematical constructs that depict how drugs are distributed and eliminated within the body. They segment the body into several compartments, symbolizing various physiological or anatomical areas connected through drug transfer processes such as absorption, metabolism, distribution, and elimination.
These models offer a more comprehensive representation of drug behavior in the body than one-compartment models. They accommodate the complexity of drug distribution,...
104

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Bayesian functional concurrent zero-inflated Dirichlet-multinomial regression model with application to infant microbiome.

Biostatistics (Oxford, England)·2026
Same author

Sociodemographic Paradoxes and Enrollment Differences in In-Person Versus Online Recruitment to a Mobile Health Smoking Cessation Intervention for Food-Insecure Adults: Secondary Analysis of a Randomized Controlled Trial.

Journal of medical Internet research·2026
Same author

Emotional words evoke region- and valence-specific patterns of concurrent neuromodulator release in human thalamus and cortex.

Cell reports·2026
Same author

A Preliminary Study of Smoking Abstinence Effects on Acquisition and Reversal Learning in a Probabilistic Learning Task.

Substance use & misuse·2026
Same author

Mobile Health Technology for Personalized Tobacco Cessation Support in Laos (Project Support Laos): Protocol for a Randomized Controlled Trial.

JMIR research protocols·2026
Same author

Effects of Ecological Momentary Assessment Prompting Schedule on Affect Measurement Variability and Associations With Next-Day Health Behaviors.

Assessment·2026
Same journal

A Tree Perspective on Stick-Breaking Models in Covariate-Dependent Mixtures (with Discussion).

Bayesian analysis·2026
Same journal

Coarsened Mixtures of Hierarchical Skew Normal Kernels for Flow and Mass Cytometry Analyses.

Bayesian analysis·2026
Same journal

Bayesian Inference for Spatial-Temporal Non-Gaussian Data Using Predictive Stacking.

Bayesian analysis·2026
Same journal

A Two-Component <i>G</i>-Prior for Variable Selection.

Bayesian analysis·2026
Same journal

Logistic-Beta Processes for Dependent Random Probabilities with Beta Marginals.

Bayesian analysis·2026
Same journal

Gridding and Parameter Expansion for Scalable Latent Gaussian Models of Spatial Multivariate Data.

Bayesian analysis·2025
See all related articles

Related Experiment Video

Updated: Jun 9, 2025

A Simple Stimulatory Device for Evoking Point-like Tactile Stimuli: A Searchlight for LFP to Spike Transitions
07:34

A Simple Stimulatory Device for Evoking Point-like Tactile Stimuli: A Searchlight for LFP to Spike Transitions

Published on: March 25, 2014

9.8K

Functional Concurrent Regression Mixture Models Using Spiked Ewens-Pitman Attraction Priors.

Mingrui Liang1, Matthew D Koslovsky2, Emily T Hébert3

  • 1Department of Statistics, Rice University, Houston, TX, USA.

Bayesian Analysis
|October 28, 2024
PubMed
Summary
This summary is machine-generated.

This study introduces a new Bayesian model for functional data analysis, simultaneously identifying key variables and grouping subjects. This approach enhances understanding of complex relationships in areas like health interventions.

Keywords:
Ewens-Pitman Attraction distributionclusteringfunctional data analysisspiked nonparametric priorsvariable selection

More Related Videos

Author Spotlight: Evaluation of Protein-Condensate Dynamics in Live Human Cells
06:48

Author Spotlight: Evaluation of Protein-Condensate Dynamics in Live Human Cells

Published on: January 5, 2024

3.4K
A Workflow for Lipid Nanoparticle LNP Formulation Optimization using Designed Mixture-Process Experiments and Self-Validated Ensemble Models SVEM
13:54

A Workflow for Lipid Nanoparticle LNP Formulation Optimization using Designed Mixture-Process Experiments and Self-Validated Ensemble Models SVEM

Published on: August 18, 2023

4.4K

Related Experiment Videos

Last Updated: Jun 9, 2025

A Simple Stimulatory Device for Evoking Point-like Tactile Stimuli: A Searchlight for LFP to Spike Transitions
07:34

A Simple Stimulatory Device for Evoking Point-like Tactile Stimuli: A Searchlight for LFP to Spike Transitions

Published on: March 25, 2014

9.8K
Author Spotlight: Evaluation of Protein-Condensate Dynamics in Live Human Cells
06:48

Author Spotlight: Evaluation of Protein-Condensate Dynamics in Live Human Cells

Published on: January 5, 2024

3.4K
A Workflow for Lipid Nanoparticle LNP Formulation Optimization using Designed Mixture-Process Experiments and Self-Validated Ensemble Models SVEM
13:54

A Workflow for Lipid Nanoparticle LNP Formulation Optimization using Designed Mixture-Process Experiments and Self-Validated Ensemble Models SVEM

Published on: August 18, 2023

4.4K

Area of Science:

  • Functional Data Analysis
  • Bayesian Statistics
  • Machine Learning

Background:

  • Functional concurrent regression models analyze data where both predictors and outcomes are functions observed over time.
  • Existing methods often address functional variable selection and clustering of subject trajectories separately.
  • A simultaneous approach is needed to integrate these tasks for a more comprehensive analysis.

Purpose of the Study:

  • To develop a novel fully Bayesian functional concurrent regression mixture model.
  • To simultaneously perform functional variable selection and clustering of subject-specific trajectories.
  • To investigate dynamic relationships between smoking behaviors and risk factors in a smoking cessation study.

Main Methods:

  • Proposed a fully Bayesian functional concurrent regression mixture model.
  • Introduced a novel spiked Ewens-Pitman attraction prior for joint clustering and variable selection.
  • Utilized auxiliary covariate patterns to inform clustering allocation.
  • Evaluated performance using simulated data and compared with alternative spiked processes.

Main Results:

  • The proposed model effectively performs simultaneous functional variable selection and clustering.
  • Demonstrated robust performance in clustering, variable selection, and parameter estimation via simulations.
  • Identified dynamic relationships between smoking behaviors and risk factors in a real-world smoking cessation intervention.

Conclusions:

  • The novel Bayesian approach offers a unified framework for functional variable selection and clustering.
  • This method provides a powerful tool for analyzing complex functional data in various scientific domains.
  • The application highlights the model's utility in understanding individual-level dynamics in health interventions.