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Development of citric acid-based biomaterials for biomedical applications
Shihao Zhang1, Cailin Liu1, Meng Su2
1Engineering Research Center for Biomedical Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Material Science & Engineering, East China University of Science and Technology, Shanghai 200237, China. yulinli@ecust.edu.cn.
Citrate-based biomaterials offer controllable preparation and versatile properties for biomedical applications. This review highlights their physical, chemical, and biological advantages for tissue engineering and drug delivery.
Area of Science:
- Biomedical Engineering
- Materials Science
Background:
- Bioactive materials with controllable preparation are crucial for biomedical engineering.
- Citrate-based biomaterials possess advantageous properties like simple synthesis, controllable structure, biocompatibility, and tunable biodegradability.
Purpose of the Study:
- To review the development of multifunctional citrate-based biomaterials.
- To summarize their physical, chemical, and biological properties.
- To outline their applications in various biomedical fields.
Main Methods:
- Literature review of citrate-based biomaterials.
- Analysis of physical, chemical, and biological properties.
- Compilation of applications in biomedical engineering.
Main Results:
- Citrate-based biomaterials exhibit controllable preparation and multifunctional properties.
- These materials demonstrate biocompatibility, biomimetic mechanical behavior, and controllable degradation.
- Diverse applications include bone and skin tissue engineering, drug/cell delivery, vascular/neural tissue engineering, and bioimaging.
Conclusions:
- Multifunctional citrate-based biomaterials are highly promising for advancing biomedical engineering.
- Their tunable properties and diverse applications underscore their significance.
- Further research can optimize these materials for enhanced clinical translation.
