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A Fibrous-Porous Microsphere-Based Composite Filler for Synchronized Immediate and Long-Term Soft Tissue Restoration.

Ruixian Lian1, Qize Li2, Dong Zhou1

  • 1The Key Laboratory for Ultrafine Materials of Ministry of Education, Engineering Research Centre for Biomedical Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.

ACS Applied Materials & Interfaces
|April 8, 2026
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Summary

This study introduces a novel composite dermal filler combining hyaluronic acid (HA) and poly-L-lactic acid-methoxypolyethyleneglycol (PLLA-mPEG) microspheres. The new filler improves early skin appearance and promotes long-term collagen regeneration for sustained volume restoration.

Keywords:
Composite fillercollagen stimulationfibrous porous microspherepoly(lactic acid) copolymersoft tissue regeneration

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Dermatology

Background:

  • Current injectable fillers have limitations in transient efficacy and early-stage improvement.
  • Developing fillers with enhanced early performance and long-term regenerative capacity is crucial for treating skin laxity and soft tissue defects.

Purpose of the Study:

  • To develop and evaluate a composite dermal filler combining hyaluronic acid (HA) and poly-L-lactic acid-methoxypolyethyleneglycol (PLLA-mPEG) microspheres.
  • To assess the filler's ability to improve early skin appearance and stimulate endogenous collagen regeneration for sustained volume restoration.

Main Methods:

  • Fabrication of a composite dermal filler with a unique fibrous porous structure using HA and PLLA-mPEG microspheres.
  • Evaluation of the filler's performance in a rat model, assessing cell proliferation, macrophage infiltration, TGF-β expression, and collagen regeneration.

Main Results:

  • The composite filler demonstrated rapid initial release of lactic acid, accelerating early cell proliferation and improving initial skin appearance.
  • In vivo studies showed the filler orchestrated a pro-regenerative microenvironment, upregulating TGF-β and stimulating significant endogenous collagen regeneration.
  • Sustained volume restoration was observed due to enhanced tissue remodeling and collagenesis.

Conclusions:

  • The composite dermal filler effectively synchronizes immediate correction with long-term tissue remodeling.
  • This innovative filler holds significant promise for the treatment of skin laxity and soft tissue defects.
  • The unique architecture and composition of the filler overcome limitations of current injectable treatments.