Related Experiment Video
Updated: Jun 9, 2025
10:43
Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
Published on: December 23, 2022
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Squamous Cell Carcinoma with Prominent Eosinophils.
Thomas N Helm1, Sanica Bhele2, Julie C Fanburg-Smith3
1Departments of Dermatology and Pathology, Penn State Hershey Medical Center, 500 University Drive Box 850/ HU-14, Hershey, PA, 17033, USA. thelm3@pennstatehealth.psu.edu.
Head and Neck Pathology
|October 28, 2024
Summary
Eosinophil infiltration in squamous cell carcinoma stroma may offer diagnostic and prognostic insights. Identifying eosinophils on routine biopsies could improve patient evaluation and treatment strategies.
Area of Science:
- Oncology
- Immunology
- Pathology
Background:
- Eosinophils are immune cells frequently found in the tumor microenvironment.
- Their presence in squamous cell carcinomas (SCC) is a notable pathological feature.
Purpose of the Study:
- To review the existing literature on the role of eosinophils in SCC.
- To explore the potential diagnostic and prognostic value of eosinophil infiltration in SCC specimens.
Main Methods:
- Literature review of studies investigating eosinophils in squamous cell carcinomas.
- Analysis of research on the identification of eosinophils in routine histopathological specimens.
Main Results:
- Eosinophils are consistently observed in the stroma and peritumoral areas of SCC.
- The extent of eosinophil infiltration is being investigated for its correlation with diagnostic and prognostic factors.
Conclusions:
- Eosinophil infiltration in SCC is a significant feature with potential clinical relevance.
- Further research is warranted to fully elucidate the diagnostic and prognostic implications of eosinophils in SCC.
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