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Updated: Jun 9, 2025

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
Published on: December 23, 2022
Squamous Cell Carcinoma with Prominent Eosinophils
Thomas N Helm1, Sanica Bhele2, Julie C Fanburg-Smith3
1Departments of Dermatology and Pathology, Penn State Hershey Medical Center, 500 University Drive Box 850/ HU-14, Hershey, PA, 17033, USA. thelm3@pennstatehealth.psu.edu.
Abstract:
Eosinophils are often encountered in the stroma and peritumoral microenvironment of squamous cell carcinomas. Because eosinophils are readily identified on routine hematoxylin and eosin stained sections, researchers have explored multiple ways in which identifying the extent of eosinophil infiltration on routine biopsy and excisional specimens might provide diagnostic and prognostic information. We review the literature on this evolving topic.
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