Deprescribing strategies for proton pump inhibitors

Area of Science:

• Gastroenterology
• Pharmacology
• Clinical Medicine

Background:

• Proton pump inhibitors (PPIs) are frequently prescribed for acid-related gastrointestinal disorders.
• While effective and well-tolerated for short-term use, long-term PPI therapy is linked to potential adverse events.

Purpose of the Study:

• To review the established indications for both short-term and long-term use of PPIs.
• To present evidence-based strategies for the deprescription of PPIs to reduce inappropriate utilization.

Main Methods:

• Literature review of clinical guidelines and research on PPI efficacy and safety.
• Analysis of studies focusing on PPI deprescribing interventions and patient outcomes.

Main Results:

• Appropriate indications for PPI use were identified, differentiating between short-term and long-term needs.
• Several deprescribing strategies were discussed, highlighting their potential to reduce PPI exposure.

Conclusions:

• Judicious use of PPIs based on clear indications is crucial.
• Implementing deprescribing strategies can mitigate risks associated with long-term PPI therapy and improve patient safety.