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SIRT1: a potential therapeutic target for coronary heart disease combined with anxiety or depression

Hubin Yu1, Xinping Li1, Bo Ning1

  • 1School of Graduate, Shaanxi University of Chinese Medicine, Xianyang, China.

Journal of Drug Targeting
|October 29, 2024
PubMed

Insights

Silent Information Regulatory Factor 1 (SIRT1) shows promise for treating coronary heart disease (CHD) with anxiety or depression. This review explores SIRT1

Area of Science:

  • Cardiology
  • Neuroscience
  • Biochemistry

Background:

  • Comorbidity of coronary heart disease (CHD) with anxiety or depression is a growing clinical concern.
  • Understanding the pathological mechanisms underlying this comorbidity is crucial for effective treatment.
  • Silent Information Regulatory Factor 1 (SIRT1) is emerging as a key factor in this complex interplay.

Purpose of the Study:

  • To comprehensively review the structure, function, and mechanisms of SIRT1.
  • To elucidate the protective roles of SIRT1 in the cardiovascular and nervous systems.
  • To highlight the therapeutic potential of SIRT1 in managing CHD comorbid with anxiety or depression.

Main Methods:

  • Literature review of existing research on SIRT1.
  • Analysis of SIRT1's molecular mechanisms, including inflammatory response and oxidative stress.
  • Examination of SIRT1's role in various signaling pathways.

Main Results:

  • SIRT1 demonstrates significant cardioprotective and neuroprotective effects.
  • SIRT1 regulates inflammatory cytokine levels and alleviates oxidative stress.
  • SIRT1 activates multiple signaling pathways relevant to cardiovascular and neurological health.

Conclusions:

  • SIRT1 presents a promising therapeutic target for CHD combined with anxiety or depression.
  • SIRT1 may serve as a valuable biomarker for this comorbidity.
  • Further research into SIRT1's mechanisms can lead to novel treatment strategies.

Keywords:
Coronary heart disease (CHD)anxietybiomarkersdepressionsilence-message regulator 1 (SIRT1)

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