Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Contingent negative variation in headache.

A Maertens de Noordhout, M Timsit-Berthier, M Timsit

    Annals of Neurology
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effectiveness, safety, and cost-utility of a knee brace in medial knee osteoarthritis: the ERGONOMIE randomized controlled trial.

    Osteoarthritis and cartilage·2021
    Same author

    Monoclonal antibodies blocking CGRP transmission: An update on their added value in migraine prevention.

    Revue neurologique·2020
    Same author

    About a case of Wernicke's encephalopathy after sleeve gastrectomy.

    Eating and weight disorders : EWD·2016
    Same author

    [Benefits and usability of a pharmaceutical record in medical practice. A survey of hospital doctors and pharmacists (MATRIX study)].

    Revue d'epidemiologie et de sante publique·2016
    Same author

    Comorbidities and factors associated with central nervous system infections and death in non-perinatal listeriosis: a clinical case series.

    BMC infectious diseases·2016
    Same author

    [Not Available].

    Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie·2015
    Same journal

    Reply to "Clinical Value of Aneurysm Wall Enhancement in Unruptured Intracranial Aneurysm".

    Annals of neurology·2026
    Same journal

    Clinical Value of Aneurysm Wall Enhancement in Unruptured Intracranial Aneurysm.

    Annals of neurology·2026
    Same journal

    Imaging of Neurovascular Compression in Thoracic Outlet Syndrome.

    Annals of neurology·2026
    Same journal

    Reply to "Methodological Challenges in Interpreting SAA-Defined Imaging Subgroups in Parkinson's Disease".

    Annals of neurology·2026
    Same journal

    Methodological Challenges in Interpreting SAA-Defined Imaging Subgroups in Parkinson's Disease.

    Annals of neurology·2026
    Same journal

    The Financial Value of an Academic Neurologist.

    Annals of neurology·2026
    See all related articles

    Contingent negative variation (CNV) brain potentials were analyzed in headache patients. Migraine patients showed significantly increased CNV amplitude, suggesting it may be a useful diagnostic marker for migraine.

    Area of Science:

    • Neuroscience
    • Clinical Neurology
    • Electrophysiology

    Background:

    • Contingent negative variation (CNV) is an event-related slow cerebral potential.
    • Headache disorders, particularly migraine, represent a significant neurological challenge.
    • Understanding the neurophysiological underpinnings of different headache types is crucial for diagnosis.

    Purpose of the Study:

    • To investigate contingent negative variation (CNV) amplitudes in patients with various headache types.
    • To determine if CNV can serve as a diagnostic biomarker for differentiating headache conditions.
    • To explore potential neurochemical correlates of altered CNV in migraine.

    Main Methods:

    • Analysis of CNV in 79 consecutive headache patients and 33 normal controls.

    Related Experiment Videos

  • Categorization of patients into tension headache, migraine, and combined headache groups.
  • Comparison of mean CNV amplitudes across patient groups and controls, studied between attacks and without medication.

    • Main Results:

    • No significant difference in CNV amplitude was observed between tension headache patients and normal controls.
    • A statistically significant increase (p < 0.001) in mean CNV amplitude was found in migraine patients.
    • Elevated CNV amplitude was also noted in patients with combined headaches having a predominant migraine component.

    Conclusions:

    • Increased CNV amplitude may serve as a valuable diagnostic indicator for migraine.
    • The heightened CNV in migraineurs could potentially reflect central catecholaminergic hyperactivity.
    • Further research into CNV's role in headache pathophysiology is warranted.