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  1. Home
  3. Systemic Lupus Erythematosus With Podocyte Infolding Glomerulopathy: A Case Report And Literature Review.
  1. Home
  3. Systemic Lupus Erythematosus With Podocyte Infolding Glomerulopathy: A Case Report And Literature Review.

Related Experiment Video

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
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Systemic lupus erythematosus with podocyte infolding glomerulopathy: A case report and literature review.

Huiqing Zhang1, Jie Lin, Hanqi Lu

  • 1Guangzhou University of Chinese Medicine, Dongguan Hospital of Traditional Chinese Medicine, Dongguan, Guangdong 523000, China.

Medicine
|October 29, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Podocyte infolding glomerulopathy (PIG), a rare kidney disease, was diagnosed in a patient with systemic lupus erythematosus (SLE). Treatment stabilized the condition, highlighting the importance of renal biopsy in autoimmune disease patients with proteinuria.

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Area of Science:

  • Nephrology
  • Rheumatology
  • Pathology

Background:

  • Podocyte infolding glomerulopathy (PIG) is a rare glomerular disease diagnosed via kidney pathology.
  • PIG is infrequently reported but can be associated with connective tissue diseases.

Observation:

  • A 34-year-old female with a decade of facial erythema and proteinuria, previously diagnosed with systemic lupus erythematosus (SLE).
  • Renal biopsy confirmed PIG in the context of ongoing proteinuria.

Findings:

  • Treatment with methylprednisolone, hydroxychloroquine sulfate, mycophenolate mofetil, and candesartan ester resolved proteinuria.
  • The patient's condition improved and remained stable following immunosuppressive therapy.

Implications:

  • This case highlights the association between SLE and PIG.
  • Careful examination of renal biopsies in autoimmune patients with proteinuria is crucial for identifying PIG cases.
  • Early diagnosis and appropriate immunosuppressive therapy can lead to stable disease outcomes.