Related Experiment Video
Updated: Jun 9, 2025

Metacarpal Small Incision for Carpal Tunnel Syndrome
Published on: April 5, 2024
Mediators of the association between educational attainment and carpal tunnel syndrome: A 2-sample, 2-step Mendelian
Yunrong Lai1, Weiquan Hu2, Suping Hu3
1Department of Imaging, Fifth People's Hospital of Ganzhou, Ganzhou, Jiangxi, China.
Abstract:
To clarify the causal relationship and potential mediators between educational attainment and carpal tunnel syndrome (CTS), as well as to evaluate whether educational attainment, cognition, and intelligence independently exert causal effects on CTS, we employed univariable Mendelian randomization (MR), multivariable MR, reverse MR, and 2-step MR approaches. Our research demonstrates that educational attainment exerts an independent causal effect on CTS, with this causal relationship being unidirectional. Five mediators were identified as significant influencers within the causal pathways connecting educational attainment and CTS. Targeting these mediators may be beneficial in the prevention of CTS.
Related Concept Videos
Coronary Artery Disease I: Introduction
Incomplete Dominance
Pedigree Analysis
Strategies for Assessing and Addressing Confounding
Confounding can be addressed at both the design phase of a study and through analytical methods after data...
Sex-linked Disorders
Confounding in Epidemiological Studies

