[Thomicide biosynthesis during the cultivation of Streptococcus sp. strain Thom-1606 on a medium of various...

The influence of different concentrations of carbohydrates on biosynthesis of thomicide, an antibacterial agent was studied. Inhibition of sugar consumption beginning at the calculated concentration of more than 1 per cent was shown. The excess of carbohydrates (not consumed carbohydrates) did not inhibit the culture growth and biosynthesis of thomicide. Sucrose in a concentration of 1 per cent proved to be the most optimal carbohydrate substrate for accumulation and preservation of the thomicide activity. Enrichment of the nutrient medium with carbohydrates in the calculated concentrations of 0.5 to 4 per cent promoted an increase in the cell dry weight accompanied by intensive synthesis of biopolymers.