Bisphenol AF Induces Alterations in the Plasma Lipidome of Rats: An Untargeted Lipidomics Approach

Bisphenol AF has gained popularity as a substitute for bisphenol A in industrial applications, leading to its detection in various biological fluids and raising concerns for public health. While the effects of bisphenol A on lipid metabolism are known, the impact of bisphenol AF on different lipid classes remains understudied. This study aimed to address this gap by conducting an untargeted lipidomics analysis in rats to assess the influence of bisphenol AF on lipid homeostasis. The results of the study revealed significant alterations in lipid profiles in plasma with various lipid classes being affected by bisphenol AF exposure. High-dose exposure to bisphenol AF resulted in specific changes within lipid clusters, including a decrease in the fatty acyl lipid cluster, except for 3,6,9,12,15-octadecapentaenoic acid. Additionally, the compound 9-0-acetyl GTb1(d18:1/18:0) within the gangliosides subclass of the sphingolipids and the sterol lipid clusters was also affected. These findings contribute to a better understanding of how bisphenol AF disrupts lipid metabolism and its associated health effects. This study provides valuable insights into the potential risks posed by bisphenol AF. Further research in this area is warranted to explore the mechanisms underlying the bisphenol AF-induced dysregulation of lipid metabolism and its implications for human health.