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Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

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Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
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Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
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At home e-based physical exercise programs in patients with multiple sclerosis: a scoping review.

Rafl Adnan1,2,3, Stine Gundtoft Roikjaer1,3,4, Sara Samadzadeh1,2,3,5

  • 1Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark.

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E-based physical exercise (PE) shows potential for improving multiple sclerosis (MS) symptoms, but evidence quality is low. Future research should address limitations in study design and reporting for e-based PE in people with MS.

Keywords:
e-based physical exercisee-based rehabilitation at homemultiple sclerosisphysical exerciserehabilitation

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Area of Science:

  • Neurology
  • Rehabilitation Medicine
  • Digital Health

Background:

  • Physical exercise (PE) is beneficial for people with multiple sclerosis (pwMS), yet adherence can be challenging.
  • E-based PE offers a convenient and accessible alternative for home-based rehabilitation in pwMS.

Purpose of the Study:

  • To conduct a scoping review of e-based PE interventions for adults with MS.
  • To analyze study designs, rehabilitation programs, intervention effects, and identify knowledge gaps.

Main Methods:

  • Systematic search of Embase, Medline, CINAHL, and Cochrane Library (2008-2023).
  • Included peer-reviewed articles on e-based PE home interventions for adult pwMS.
  • Focused on randomized controlled trials (RCTs) for intervention effect evaluation.

Main Results:

  • 54 studies (2,359 pwMS) included; 33 RCTs.
  • Interventions included video, telerehabilitation, and web-based programs.
  • RCTs showed improved depression/anxiety; inconsistent results for fatigue, walking, balance; no benefit for dexterity.
  • Heterogeneous results limited by small sample sizes and methodological issues.

Conclusions:

  • E-based PE may improve MS symptoms, but evidence quality is generally low.
  • Findings are inconsistent, highlighting the need for higher-quality research.
  • Identified limitations include poor reporting of intervention details and lack of baseline physical activity assessment.