Perceptions of Multicancer Detection Tests Among Primary Care Physicians and Laypersons: A Qualitative Study

Area of Science:

• Oncology
• Genomics
• Medical Diagnostics

Background:

• Multicancer detection tests (MCDs) are emerging blood-based technologies for identifying multiple cancer types.
• The clinical utility and mortality impact of MCDs remain under investigation.
• Understanding provider and patient perspectives is crucial for evaluating MCDs.

Purpose of the Study:

• To assess awareness and perceptions of MCDs among primary care physicians (PCPs) and the general public.
• To explore anticipated benefits, harms, and acceptability of cancer screening using MCDs.

Main Methods:

• Conducted six focus groups with 45 PCPs and 12 focus groups with 80 laypersons.
• Utilized semi-structured interview guides to explore knowledge, attitudes, and expectations.
• Transcribed and analyzed discussions using a developed codebook to identify emergent themes.

Main Results:

• Participants recognized MCDs' ease of use and potential for early cancer detection.
• PCPs raised concerns regarding practice guidelines, follow-up costs, privacy, insurance, and liability.
• Laypersons expressed concerns about costs, insurance, privacy, and anxiety over positive results.

Conclusions:

• Significant need exists for robust data on MCDs to guide clinical implementation.
• Development of evidence-based guidelines is essential for the responsible use of MCDs in cancer screening.