The Cancer-Specific Health Economic Measure QLU-C10D is Valid and Responsive for Assessing Health Utility in Patients...

Area of Science:

• Health Economics
• Oncology
• Psychometrics

Background:

• Health economic appraisals require reliable health utility measures.
• Preference-based measures (PBMs) are crucial for assessing utilities.
• The EORTC QLU-C10D is a cancer-specific PBM needing validation.

Purpose of the Study:

• To validate the EORTC QLU-C10D in patients with thyroid cancer.
• To assess the criterion and construct validity of the EORTC QLU-C10D.
• To compare the EORTC QLU-C10D with the EQ-5D-5L in thyroid cancer.

Main Methods:

• Multicenter, multinational prospective cohort study.
• Longitudinal collection of EORTC QLQ-C30 and EQ-5D-5L data.
• Application of country-specific value sets for utility derivation.
• Assessment of criterion validity, construct validity, known-group comparisons, and responsiveness.

Main Results:

• 181 thyroid cancer patients from nine countries provided data.
• EORTC QLU-C10D demonstrated good criterion validity (ICC 0.761-0.901).
• The measure showed sensitivity and responsiveness in detecting changes and group differences.
• EORTC QLU-C10D exhibited higher statistical efficiency than EQ-5D-5L.

Conclusions:

• The EORTC QLU-C10D is a valid and reliable PBM for thyroid cancer studies.
• The measure is suitable for health economic evaluations in this population.
• Use of EORTC QLU-C10D is recommended for estimating health utilities in thyroid cancer therapies.