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Related Concept Videos

Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...

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Fast Transfer Learning Method Using Random Layer Freezing and Feature Refinement Strategy.

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    Area of Science:

    • Artificial Intelligence
    • Machine Learning
    • Computer Vision

    Background:

    • Inductive transfer learning (ITL) utilizes pretrained deep convolutional neural networks (DCNNs).
    • Moore-Penrose inverse (MPI)-based parameter fine-tuning of fully connected (FC) layers is a recent ITL approach.
    • Current MPI-based ITL methods face challenges due to high computational demands, limiting practical application.

    Purpose of the Study:

    • To develop a novel fast retraining strategy to enhance the applicability of MPI-based ITL.
    • To address the computational bottlenecks of existing MPI-based ITL methods.
    • To improve the convergence speed of parameter fine-tuning in DCNNs.

    Main Methods:

    • Implemented a random layer freezing protocol during retraining epochs to manage feature refinement.
    • Incorporated an MPI-based approach for refining FC layer parameters under batch processing.
    • Evaluated the strategy on ImageNet pretrained benchmark DCNNs.

    Main Results:

    • The proposed ITL strategy achieves competitive performance compared to conventional ITL methods.
    • Demonstrated significantly improved convergence speed.
    • Achieved convergence nearly 1.5 times faster than standard retraining on ResNet-50 using stochastic gradient descent with momentum (SGDM).

    Conclusions:

    • The novel fast retraining strategy effectively enhances the practicality of MPI-based ITL.
    • The method offers a computationally efficient alternative for fine-tuning DCNNs.
    • This approach presents a promising direction for accelerating deep learning model adaptation.