Focal fluorescence of choroidal melanoma

The surface of the tumours of four patients with apparently dormant small choroidal melanomas showed a distinct, localised, hyperfluorescent zone by fluorescein angiography. It was interpreted as being secondary to atrophy of the retinal pigment epithelium. In each patient later growth of the tumour was evidenced by its eruption through Bruch's membrane at this same site. This angiographic finding may predict a tumour that is prone to grow and break through Bruch's membrane at that location.