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Management of 10 Children With Inflammatory Rosacea With Topical Ivermectin
Federica Dall'Oglio1, Maria Rita Nasca1, Aurora Tedeschi1
1Dermatology Clinic, University of Catania, Catania, Italy.
Pediatric Dermatology
|October 31, 2024
Summary
Ivermectin (IVM) 1% cream applied once daily effectively treated inflammatory rosacea in 10 children over 12 weeks. This study suggests IVM cream is a promising therapeutic option for pediatric rosacea.
Area of Science:
- Dermatology
- Pediatric Medicine
- Pharmacology
Background:
- Rosacea diagnosis and treatment in children present unique challenges due to its rarity.
- There is a lack of approved pharmacological treatments for pediatric rosacea.
Purpose of the Study:
- To evaluate the clinical response to once-daily ivermectin (IVM) 1% cream in children with mild to severe inflammatory rosacea.
- To assess the efficacy of IVM cream using both clinical and instrumental monitoring methods.
Main Methods:
- A case series involving 10 children with inflammatory rosacea treated with IVM 1% cream for 12 weeks.
- Clinical evaluation included Investigator Erythema Severity Assessment (IESA) and Investigator Global Assessment of Severity (IGA-S).
- Instrumental monitoring utilized dermoscopy and Erythema-Directed Digital Photography (EDDP).
Main Results:
- Significant clinical improvement was observed post-treatment compared to baseline (IESA: 2.3 vs. 0.5; IGA-S: 2.1 vs. 0.3).
- Investigator Global Assessment of Global Efficacy (IGA-GE) showed positive outcomes (0=55%, 1=33%, 3=11%).
- Instrumental monitoring confirmed clinical findings (EDDP: 2.7 vs. 0.6).
Conclusions:
- Once-daily application of ivermectin 1% cream demonstrated effectiveness in treating pediatric rosacea.
- IVM cream may represent a viable therapeutic option for children diagnosed with rosacea.
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