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Curcumin on Human Health: A Comprehensive Systematic Review and Meta-Analysis of 103 Randomized Controlled Trials.

Ali Jafari1,2, Maryam Abbastabar3, Alireza Alaghi2,4

  • 1Student Research Committee, Department of Community Nutrition, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Phytotherapy Research : PTR
|October 31, 2024
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Curcumin supplementation shows significant effects on fasting blood sugar, lipid profiles, and inflammation markers. Further high-quality trials are needed to confirm these benefits for various health outcomes.

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curcuminhealth‐related outcomeshuman healthturmeric yellow

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Area of Science:

  • Pharmacology and Therapeutics
  • Nutritional Science
  • Evidence-Based Medicine

Background:

  • Curcumin, derived from Curcuma longa L., is recognized for its potential health benefits.
  • Numerous randomized clinical trials (RCTs) have investigated curcumin's impact on diverse health outcomes.
  • A comprehensive synthesis of existing evidence is crucial for understanding curcumin's therapeutic potential.

Purpose of the Study:

  • To conduct a meta-analysis evaluating the effects of curcumin supplementation on a wide array of health outcomes.
  • To synthesize evidence from RCTs comparing curcumin with placebo.
  • To assess the certainty of evidence for each outcome using GRADE criteria.

Main Methods:

  • Systematic search of PubMed, EMBASE, Scopus, and Web of Science databases up to September 2023.
  • Inclusion of RCTs comparing Curcuma longa L. (curcumin) with placebo.
  • Meta-analysis of effect sizes using a random-effects model; risk of bias and certainty of evidence assessed.

Main Results:

  • 103 RCTs with 7216 participants were included, examining 42 outcomes.
  • Statistically significant effects were observed in 23 out of 42 outcomes (55%).
  • High certainty evidence supported curcumin's effects on fasting blood sugar (FBS), C-reactive protein (CRP), high-density lipoprotein (HDL), and weight.

Conclusions:

  • Curcumin supplementation positively influences FBS, glycemic indices, lipid profiles, and inflammatory/oxidative markers.
  • Evidence quality varies, with high certainty for specific metabolic and inflammatory markers.
  • Further well-designed, large-scale, long-term RCTs are recommended to strengthen the evidence base.