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Related Experiment Video

Updated: Jun 9, 2025

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials

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Published on: August 13, 2019

Two Stage Sinus Lifting Using Nanohydroxyapatite Particles Versus Deproteinized Bovine Bone: Randomized Clinical

Mahmoud Nour¹, Mohamed Shawky², Rofaida A Abaas²

¹Department of Oral Implantology, Faculty of Dentistry, Cairo University, Cairo, Egypt.

Clinical Implant Dentistry and Related Research

|October 31, 2024

Summary

This study compared nanohydroxyapatite (NHA) and deproteinized bovine bone (DBB) for sinus augmentation. Both biomaterials demonstrated comparable bone regeneration quality and quantity, showing no significant differences in outcomes.

Keywords:

DBB NHA bone augmentation dental implants histomorphometry sinus lifting

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Last Updated: Jun 9, 2025

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Area of Science:

Oral and Maxillofacial Surgery
Regenerative Medicine
Biomaterials Science

Background:

Sinus floor elevation is a key procedure for augmenting vertically deficient maxillary alveolar ridges.
Xenografts and hydroxyapatite are established biomaterials for sinus augmentation.
Comparing novel biomaterials like nanohydroxyapatite with traditional ones is crucial for advancing augmentation techniques.

Purpose of the Study:

To compare the bone quality and quantity generated by nanohydroxyapatite (NHA) versus deproteinized bovine bone (DBB) in sinus augmentation procedures.
To evaluate the efficacy of NHA as a bone graft substitute in comparison to a widely used xenograft.

Main Methods:

A randomized controlled trial involving 24 patients undergoing sinus floor elevation.
Augmentation was performed using either NHA or DBB (control group).
Bone height was measured preoperatively, immediately postoperatively, and at 6 months; histological and histomorphometric analyses assessed bone quality.

Main Results:

Both NHA and DBB groups showed good bone consolidation with no significant difference in mean bone height at 6 months (11.72 mm vs 12.01 mm).
Histomorphometric analysis revealed no significant differences in newly formed bone percentage (29.84% vs 34.73%) or residual graft material (32.43% vs 30.43%) between NHA and DBB groups.
Histological evaluation showed no significant differences in bone regeneration parameters between the two groups.

Conclusions:

Nanohydroxyapatite (NHA) and deproteinized bovine bone (DBB) yield comparable results in terms of regenerated bone quality and quantity following sinus floor augmentation.
Further research with larger sample sizes and longer follow-up periods is recommended to solidify these findings.