Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Improving Translational Accuracy02:07

Improving Translational Accuracy

2.5K
2.5K
Translational Regulation01:29

Translational Regulation

1
Translational regulation in prokaryotes ensures efficient protein synthesis by controlling ribosome access to mRNA. This regulation is mediated by secondary RNA structures, including translational riboswitches, RNA thermometers, and small RNAs (sRNAs), which respond to intracellular and environmental signals to modulate gene expression.Translational RiboswitchesRiboswitches in the leader region of mRNAs can regulate translation by altering the accessibility of the Shine-Dalgarno (SD) sequence,...
1
Leaky Scanning02:28

Leaky Scanning

5.1K
During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
5.1K
Ribosome Profiling02:24

Ribosome Profiling

3.5K
Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
3.5K
Translation01:31

Translation

14.6K
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Proteins are...
14.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Enhancing mental and physical health of women through engagement and retention (EMPOWER) 3.0 QUERI: study protocol for a cluster-randomized hybrid type 3 implementation-effectiveness trial.

Implementation science : IS·2026
Same author

Perceived Prescription Opioid and Medical Cannabis-Related Stigma Among US Adults With and Physicians Who Treat Chronic Pain.

Drug and alcohol review·2026
Same author

Evaluating the impacts of critical time intervention implementation on health service utilization among homeless-experienced veterans: a retrospective observational study.

BMC health services research·2026
Same author

Enrollment in Integrated Special Needs Plans Among Dually Eligible Beneficiaries With Serious Mental Illness.

JAMA network open·2026
Same author

Stakeholder-informed recommendations for patient-centered medication service delivery for stimulant use disorder: a qualitative study.

Addiction science & clinical practice·2026
Same author

Research-Operational Partnerships in the Launch of a Hybrid Consumer-Operated Drop-In Center for Veterans.

Psychiatric services (Washington, D.C.)·2026

Related Experiment Video

Updated: Jun 9, 2025

Quantitative Immunofluorescence to Measure Global Localized Translation
09:13

Quantitative Immunofluorescence to Measure Global Localized Translation

Published on: August 22, 2017

9.8K

The Translational Science Benefits Model, a new training tool for demonstrating implementation science impact: A

Stephanie Andersen1, Annalee Wilson2, Todd Combs3

  • 1Clark-Fox Policy Institute, Brown School at Washington University in St. Louis, St. Louis, MO, USA.

Journal of Clinical and Translational Science
|October 31, 2024
PubMed
Summary
This summary is machine-generated.

The Translational Science Benefits Model (TSBM) helps researchers demonstrate research impact. Integrating TSBM into training networks aids in identifying and communicating diverse benefits, from community to clinical outcomes.

Keywords:
Implementation sciencedisseminationimpacttrainingtranslational science

More Related Videos

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research
09:35

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research

Published on: August 16, 2017

17.8K
Measurement of Specific Mycobacterial Mistranslation Rates with Gain-of-function Reporter Systems
06:18

Measurement of Specific Mycobacterial Mistranslation Rates with Gain-of-function Reporter Systems

Published on: April 26, 2019

5.9K

Related Experiment Videos

Last Updated: Jun 9, 2025

Quantitative Immunofluorescence to Measure Global Localized Translation
09:13

Quantitative Immunofluorescence to Measure Global Localized Translation

Published on: August 22, 2017

9.8K
A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research
09:35

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research

Published on: August 16, 2017

17.8K
Measurement of Specific Mycobacterial Mistranslation Rates with Gain-of-function Reporter Systems
06:18

Measurement of Specific Mycobacterial Mistranslation Rates with Gain-of-function Reporter Systems

Published on: April 26, 2019

5.9K

Area of Science:

  • Implementation Science
  • Translational Research
  • Health Services Research

Background:

  • Demonstrating research impact is a growing challenge in implementation science.
  • The Translational Science Benefits Model (TSBM) provides a structured approach to assess research impact.
  • Integrating impact assessment into training programs is crucial for advancing research dissemination.

Purpose of the Study:

  • To describe the integration of the TSBM into a mentored training network.
  • To pilot the TSBM with trainees in mental health implementation science.
  • To refine TSBM tools and methods based on user feedback.

Main Methods:

  • Collaboration between a Clinical and Translational Science Awards (CTSA) TSBM team and the Implementation Research Institute (IRI).
  • Phased training approach including workshops on research impact and dissemination.
  • Pilot testing of TSBM with six IRI alumni who developed case studies.

Main Results:

  • Forty benefits were identified across community, policy, economic, and clinical domains.
  • TSBM training provided a framework for discussing research impact.
  • Early-stage project researchers found benefit selection challenging, highlighting the need for early training.

Conclusions:

  • Case studies demonstrated the institute's and fellows' impact.
  • TSBM integration informed refinements for future IRI training.
  • The TSBM is a valuable tool for assessing and communicating research impact in training settings.