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Published on: August 2, 2018
Detecting carcinoembryonic antigen based on the aggregation-induced emission enhancement effect
Yanjun Lu1, Mengqi Wang1, Yiwen Yang1
1Jiaxing Key Laboratory of Molecular Recognition and Sensing, College of Biological, Chemical Sciences and Engineering, Jiaxing University, 314001, Zhejiang, China. yangyiwen@mail.zjxu.edu.cn.
Abstract:
In this study, a novel label-free fluorescent aptasensor with an aggregation-induced emission enhancement effect was developed and applied for the detection of carcinoembryonic antigen (CEA). The sensor has a simple detection mechanism, easy operation, high sensitivity (with low limit of detection of 1 pg mL-1), good selectivity, and wide linear range (0.003-10 ng mL-1). In addition, it can be directly applied for the determination of CEA in human serum.

