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Retroperitoneal Malakoplakia Mimicking Metastatic Disease
Dylan Dominguez1, Joshua Eichhorn1, Fathima Fijula Palot Manzil2
1From the Department of Radiology, University of Arkansas for Medical Sciences, Little Rock, AR.
Abstract:
Malakoplakia is a rare inflammatory granulomatous disease that can produce a tumor-like appearance in nearly any organ system. Imaging findings of malakoplakia overlap with malignancy and tissue sampling are typically required for definitive diagnosis. We present a case of a 66-year-old woman with a previous history of liver adenocarcinoma status post resection that subsequently developed an intensely FDG-avid retroperitoneal mass on surveillance imaging. CT-guided biopsy of the mass demonstrated Michaelis-Gutmann bodies, supporting the diagnosis of malakoplakia. The patient underwent antibiotic treatment with complete resolution of the mass.
Insights
Malakoplakia, a rare inflammatory disease, can mimic cancer on imaging. This case highlights its diagnosis via biopsy and successful treatment with antibiotics, leading to complete mass resolution.
Area of Science:
- Oncology
- Pathology
- Radiology
Background:
- Malakoplakia is a rare inflammatory condition presenting with tumor-like lesions across organ systems.
- Its imaging characteristics often overlap with malignancies, necessitating tissue sampling for diagnosis.
- Retroperitoneal masses can arise from various etiologies, including inflammatory processes.
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